FLICE-Like Inhibitory Protein Long Form (CFLAR) Antibody
572€ (100 µg)
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935106861
info@markelab.com
name
FLICE-Like Inhibitory Protein Long Form (CFLAR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx412444
tested applications
WB, IHC
Description
FLICE-Like Inhibitory Protein Long Form (FLIPL/CFLAR) Antibody is a Rabbit Polyclonal antibody against FLICE-Like Inhibitory Protein Long Form (FLIPL/CFLAR).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | FLICE-Like Inhibitory Protein Long Form (CFLAR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15519 |
| Alias | CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP |
| Background | Antibody anti-CFLAR |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
CASP8 and FADD-like apoptosis regulator (CFLAR), also known as c-FLIP, is an important regulatory protein that modulates apoptosis, particularly in response to death receptor signaling. CFLAR is structurally related to the caspase family but lacks protease activity, allowing it to inhibit caspase-8 activation in the death receptor pathway. By binding to the death-inducing signaling complex (DISC), CFLAR blocks the activation of downstream apoptotic signaling, effectively acting as an inhibitor of apoptosis. This inhibition allows cells to evade cell death, and as such, CFLAR has been implicated in promoting cell survival in various cancers, as well as playing a role in immune responses.
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