CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody
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935106861
info@markelab.com
Precio
221€ (50 µg)
Antibody anti-CFLAR
proveedor
Abbexareference
abx324522Tested Applications
ELISA, WB, IHCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
CFLAR Antibody is a Rabbit Polyclonal against CFLAR.
Background
CASP8 and FADD-like apoptosis regulator (CFLAR), also known as c-FLIP, is an important regulatory protein that modulates apoptosis, particularly in response to death receptor signaling. CFLAR is structurally related to the caspase family but lacks protease activity, allowing it to inhibit caspase-8 activation in the death receptor pathway. By binding to the death-inducing signaling complex (DISC), CFLAR blocks the activation of downstream apoptotic signaling, effectively acting as an inhibitor of apoptosis. This inhibition allows cells to evade cell death, and as such, CFLAR has been implicated in promoting cell survival in various cancers, as well as playing a role in immune responses.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
CASP8 And FADD Like Apoptosis Regulator (CFLAR)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1/20000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
size 1
50 µg
size 2
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
CFLAR
dry ice
No
availability
Shipped within 5-10 working days.
alias
CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP
uniprot id
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proveedor
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