CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody

Name: CASP8 And FADD Like Apoptosis Regulator (CFLAR) Antibody
Brand: Abbexa
SKU: abx034233
Price: 292.5 EUR
Availability: OnlineOnly

Este producto es parte de CFLAR - CASP8 and FADD-like apoptosis regulator

Pida mas información

935106861

info@markelab.com

Precio

292.5€ (80 µl)

Antibody anti-CFLAR

proveedor

Abbexa

reference

abx034233

Tested Applications

ELISA, WB, IHC, FCM

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. It lacks enzymatic (caspase) activity.

Background

CASP8 and FADD-like apoptosis regulator (CFLAR), also known as c-FLIP, is an important regulatory protein that modulates apoptosis, particularly in response to death receptor signaling. CFLAR is structurally related to the caspase family but lacks protease activity, allowing it to inhibit caspase-8 activation in the death receptor pathway. By binding to the death-inducing signaling complex (DISC), CFLAR blocks the activation of downstream apoptotic signaling, effectively acting as an inhibitor of apoptosis. This inhibition allows cells to evade cell death, and as such, CFLAR has been implicated in promoting cell survival in various cancers, as well as playing a role in immune responses.

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

CASP8 And FADD Like Apoptosis Regulator (CFLAR)

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB, IHC, FCM

purification

Purified Rabbit Polyclonal Antibody.

recommended dilution

WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.

buffer

PBS containing 0.09% sodium azide.

size 1

80 µl

size 2

400 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

CFLAR

dry ice

availability

Shipped within 5-10 working days.

alias

CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP

uniprot id

https://www.uniprot.org/uniprotkb/O15519

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proveedor

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reference

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reactivity

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status

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proveedor

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reference

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Tested Applications

ELISA, WB, IHC, IF, IP

reactivity

human

status

RUO

clonality

polyclonal

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