BID - BH3-interacting domain death agonist | Elisa - Clia - Antibody - Protein

Family main features

Background

BH3-interacting domain death agonist (BID) is a pro-apoptotic member of the BCL-2 protein family. BID plays a crucial role in the regulation of apoptosis, specifically in the mitochondrial pathway of cell death. It is encoded by the BID gene located on chromosome 22q11.2. BID is unique among the BCL-2 family members due to its ability to interact with both pro-apoptotic and anti-apoptotic proteins, facilitating the apoptotic signaling cascade.


Protein Structure

  • Domains: BID consists of a single BH3 (BCL-2 homology 3) domain, which is critical for its pro-apoptotic function. The BH3 domain is essential for BID's interaction with other BCL-2 family proteins.
  • Pro- and Active Forms: BID exists in an inactive form in the cytosol. Upon apoptotic stimuli, it is cleaved by caspase-8 to generate the active truncated form, tBID.
  • Alpha Helices: The protein's structure predominantly features alpha helices, which facilitate its interaction with the mitochondrial membrane and other BCL-2 family members.


Classification and Subtypes

BID belongs to the "BH3-only" subgroup of the BCL-2 family, characterized by containing only the BH3 domain. This subgroup includes other pro-apoptotic proteins such as BIM, PUMA, and BAD, which initiate apoptosis by antagonizing anti-apoptotic BCL-2 family members and activating pro-apoptotic effectors like BAX and BAK.


Function and Biological Significance

  • Apoptosis Activation: BID is a critical mediator of the mitochondrial apoptotic pathway. Upon activation by cleavage, tBID translocates to the mitochondria, where it binds to and activates BAX and BAK. This interaction leads to mitochondrial outer membrane permeabilization (MOMP), cytochrome c release, and the activation of caspases, culminating in cell death.
  • Role in Intrinsic and Extrinsic Pathways: BID links the extrinsic (death receptor-mediated) and intrinsic (mitochondrial) apoptotic pathways. Caspase-8, activated by death receptors, cleaves BID, thereby amplifying the apoptotic signal through the mitochondrial pathway.


Clinical Issues

  • Cancer: Dysregulation of BID expression or function is implicated in cancer. Reduced BID activity can contribute to resistance to apoptosis, allowing cancer cells to survive and proliferate despite therapeutic interventions.
  • Therapeutic Targeting: Modulating BID activity is a potential therapeutic strategy. Enhancing BID activation could sensitize cancer cells to apoptosis, improving the efficacy of anti-cancer therapies.
  • Neurodegenerative Diseases: BID-mediated apoptosis is also involved in neurodegenerative diseases. Abnormal activation of BID can lead to excessive neuronal cell death, contributing to diseases such as Alzheimer's and Parkinson's.


Summary

BH3-interacting domain death agonist (BID) is a pivotal pro-apoptotic protein within the BCL-2 family, playing a key role in regulating apoptosis through the mitochondrial pathway. BID is activated by cleavage into tBID, which then promotes mitochondrial membrane permeabilization and cell death. It serves as a crucial link between the extrinsic and intrinsic apoptotic pathways. Dysregulation of BID has significant implications in cancer and neurodegenerative diseases, making it a potential target for therapeutic interventions aimed at modulating apoptosis.


BID Recommended name:

BH3-interacting domain death agonist (BID)

Aliases for BID

p22 BID,FP497

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con BID - BH3-interacting domain death agonist

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Esta página contiene 62 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaBIDabx356043Chicken BH3 Interacting Domain Death Agonist (BID) ELISA KitChickenSerum, plasma and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml0.19 ng/ml68996 testsRUO
FineTestBIDEH0983Human BID(BH3-interacting domain death agonist) ELISA KithumanSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody0.313-20ng/ml96TP55957RUO
AbbexaBIDabx351363Human BH3 Interacting Domain Death Agonist (BID) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml0.19 ng/ml54696 testsP55957RUO
AbbexaBIDabx150808Human BH3 Interacting Domain Death Agonist (Bid) ELISA KitHumanTissue homogenates and other biological fluids.Sandwich1.56 ng/ml - 100 ng/ml< 0.58 ng/ml643.596 testsRUO
AbbexaBIDabx257411Human BH3 Interacting Domain Death Agonist (BID) ELISA KitHumanSerum, plasma, and other biological fluids.Sandwich62.5 pg/ml - 4000 pg/ml37.5 pg/ml54696 testsRUO
AbbexaBIDabx196483Human BH3 Interacting Domain Death Agonist (Bid) CLIA KitHumanSerum, plasma and other biological fluids.Sandwich62.5 pg/ml - 4000 pg/ml37.5 pg/ml643.596 testsRUO
AbbexaBIDabx491790Human BH3 Interacting Domain Death Agonist (Bid) CLIA KitHumanSerum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.Sandwich1.56 ng/ml - 100 ng/ml< 0.61 ng/ml84596 testsRUO
AbbexaBIDabx595062BH3-Interacting Domain Death Agonist (BID) Cell ELISA KitHuman513.596 testsP55957RUO
FineTestBIDEM0871Mouse Bid(BH3 Interacting Domain Death Agonist) ELISA KitmouseSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody 0.313-20ng/ml96TP70444RUO
AbbexaBIDabx196752Mouse BH3 Interacting Domain Death Agonist (Bid) CLIA KitMouseSerum, plasma and other biological fluids.Sandwich62.5 pg/ml - 4000 pg/ml37.5 pg/ml643.596 testsRUO
AbbexaBIDabx491791Mouse BH3 Interacting Domain Death Agonist (Bid) CLIA KitMouseSerum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml< 0.112 ng/ml84596 testsRUO
AbbexaBIDabx255211Mouse BH3 Interacting Domain Death Agonist (BID) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml0.19 ng/ml54696 testsP70444RUO
AbbexaBIDabx153712Mouse BH3 Interacting Domain Death Agonist (Bid) ELISA KitMouseTissue homogenates and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml< 0.13 ng/ml61196 testsRUO
AbbexaBIDabx360959Pig BH3 Interacting Domain Death Agonist (BID) ELISA KitPigSerum, plasma and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml0.19 ng/ml71596 testsRUO
FineTestBIDER0336Rat Bid(BH3-interacting domain death agonist) ELISA KitratSerum,Plasma,Tissue homogenates,Other biological fluidsSandwich ELISA, Double Antibody0.313-20ng/ml96TQ9JLT6RUO
AbbexaBIDabx196753Rat BH3 Interacting Domain Death Agonist (BID) CLIA KitRatSerum, plasma and other biological fluids.Sandwich62.5 pg/ml - 4000 pg/ml37.5 pg/ml643.596 testsRUO
AbbexaBIDabx155258Rat BH3 Interacting Domain Death Agonist (Bid) ELISA KitRatTissue homogenates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.07 ng/ml70296 testsRUO
AbbexaBIDabx256314Rat BH3 Interacting Domain Death Agonist (BID) ELISA KitRatTissue homogenates, cell lysates and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml0.19 ng/ml552.596 testsQ9JLT6RUO
AbbexaBIDabx491792Rat BH3 Interacting Domain Death Agonist (Bid) CLIA KitRatSerum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.067 ng/ml84596 testsRUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
FineTestBIDFNab00893anti- BID antibodyhumanmonoclonalMouseBH3 interacting domain death agonistIgG2aUnconjugatedELISA, WB100µgP55957RUO
FineTestBIDFNab00892anti- BID antibodyhumanpolyclonalRabbitBH3 interacting domain death agonistIgGUnconjugatedELISA, WB, IHC100µgP55957RUO
AbbexaBIDabx103691BH3 Interacting Domain Death Agonist (Bid) AntibodyHumanPolyclonalRabbitBH3 Interacting Domain Death Agonist (Bid)UnconjugatedWB, IHC, IF/ICC250100 µlP55957RUO
AbbexaBIDabx137416BH3 Interacting Domain Death Agonist (BID) AntibodyHumanMonoclonalMouseBH3 Interacting Domain Death Agonist (BID)Unconjugated2255 µgRUO
AbbexaBIDabx272017BH3 Interacting Domain Death Agonist (Bid) Antibody (Biotin)HumanPolyclonalRabbitBH3 Interacting Domain Death Agonist (Bid)BiotinWB, IHC, IF/ICC337.5200 µlRUO
AbbexaBIDabx273774BH3 Interacting Domain Death Agonist (Bid) Antibody (FITC)HumanPolyclonalRabbitBH3 Interacting Domain Death Agonist (Bid)FITCWB, IHC, IF/ICC400200 µlRUO
AbbexaBIDabx111223BH3-Interacting Domain Death Agonist (BID) AntibodyHumanPolyclonalRabbitBH3-Interacting Domain Death Agonist (BID)UnconjugatedELISA, WB, IHC612.5100 µlP55957RUO
AbbexaBIDabx230892BH3-Interacting Domain Death Agonist (BID) AntibodyHumanPolyclonalRabbitBH3-Interacting Domain Death Agonist (BID)UnconjugatedELISA, WB, IHC, IF/ICC, IP350100 µgP55957RUO
AbbexaBIDabx230893BH3-Interacting Domain Death Agonist (BID) AntibodyHumanMonoclonalMouseBH3-Interacting Domain Death Agonist (BID)UnconjugatedELISA, WB350100 µgP55957RUO
AbbexaBIDabx323329BH3-Interacting Domain Death Agonist (BID) AntibodyHumanPolyclonalRabbitBH3-Interacting Domain Death Agonist (BID)UnconjugatedELISA, WB187.550 µgP55957RUO
AbbexaBIDabx339965BH3-Interacting Domain Death Agonist (BID) AntibodyHumanPolyclonalRabbitBH3-Interacting Domain Death Agonist (BID)UnconjugatedELISA, WB, IHC25050 µlP55957RUO
AbbexaBIDabx432407BH3-Interacting Domain Death Agonist (BID) AntibodyHumanPolyclonalGoatBH3-Interacting Domain Death Agonist (BID)UnconjugatedP-ELISA, WB, IF/ICC387.5200 µlRUO
AbbexaBIDabx105190BH3-Interacting Domain Death Agonist (BID) Antibody (Biotin)HumanPolyclonalRabbitBH3-Interacting Domain Death Agonist (BID)BiotinELISA162.520 µgP55957RUO
AbbexaBIDabx108024BH3-Interacting Domain Death Agonist (BID) Antibody (HRP)HumanPolyclonalRabbitBH3-Interacting Domain Death Agonist (BID)HRPELISA162.520 µgP55957RUO
AbbexaBIDabx031834Bid (pS65) AntibodyHumanPolyclonalRabbitBid (pS65)UnconjugatedELISA, WB, IHC281.2580 µlP55957RUO
AbbexaBIDabx370064BH3 Interacting Domain Death Agonist (Bid) Antibody PairHumanBH3 Interacting Domain Death Agonist (Bid)ELISA1212.55 × 96 testsRUO
AbbexaBIDabx339966BH3-Interacting Domain Death Agonist (BID) AntibodyHumanPolyclonalRabbitBH3-Interacting Domain Death Agonist (BID)UnconjugatedELISA, WB, IHC25050 µlP55957RUO
AbbexaBIDabx171416BH3 Interacting Domain Death Agonist (Bid) AntibodyHumanMonoclonalMouseBH3 Interacting Domain Death Agonist (Bid)UnconjugatedWB, IHC, IF/ICC712.51 mlRUO
AbbexaBIDabx011976BH3-Interacting Domain Death Agonist (BID) AntibodyHumanMonoclonalMouseBH3-Interacting Domain Death Agonist (BID)UnconjugatedELISA, WB, IHC, IF/ICC, FCM362.5100 µlP55957RUO
AbbexaBIDabx109577BH3-Interacting Domain Death Agonist (BID) AntibodyHumanPolyclonalRabbitBH3-Interacting Domain Death Agonist (BID)UnconjugatedELISA, IHC162.520 µgP55957RUO
AbbexaBIDabx106607BH3-Interacting Domain Death Agonist (BID) Antibody (FITC)HumanPolyclonalRabbitBH3-Interacting Domain Death Agonist (BID)FITC162.520 µgP55957RUO
AbbexaBIDabx027196BH3 Interacting Domain Death Agonist (BID) AntibodyHumanPolyclonalRabbitBH3 Interacting Domain Death Agonist (BID)UnconjugatedELISA, WB, IHC281.2580 µlP55957RUO
AbbexaBIDabx325265BH3-Interacting Domain Death Agonist Phospho-Ser78 (BID pS78) AntibodyHumanPolyclonalRabbitBH3-Interacting Domain Death Agonist Phospho-Ser78 (BID pS78)UnconjugatedELISA, IHC187.550 µgP55957RUO
AbbexaBIDabx325731BH3-Interacting Domain Death Agonist (BID) AntibodyHumanPolyclonalRabbitBH3-Interacting Domain Death Agonist (BID)UnconjugatedELISA, WB, IHC187.550 µgP55957RUO
AbbexaBIDabx000598BH3-Interacting Domain Death Agonist (BID) AntibodyHumanPolyclonalRabbitBH3-Interacting Domain Death Agonist (BID)UnconjugatedWB, IF/ICC17520 µlP55957RUO
AbbexaBIDabx103690BH3 Interacting Domain Death Agonist (Bid) AntibodyMousePolyclonalRabbitBH3 Interacting Domain Death Agonist (Bid)UnconjugatedWB, IHC, IF/ICC237.5100 µlP70444RUO
AbbexaBIDabx272722BH3 Interacting Domain Death Agonist (Bid) Antibody (Biotin)MousePolyclonalRabbitBH3 Interacting Domain Death Agonist (Bid)BiotinWB, IHC, IF/ICC312.5200 µlRUO
AbbexaBIDabx370243BH3 Interacting Domain Death Agonist (Bid) Antibody PairMouseBH3 Interacting Domain Death Agonist (Bid)ELISA1212.55 × 96 testsRUO
AbbexaBIDabx027197BH3-Interacting Domain Death Agonist (BID) AntibodyMousePolyclonalRabbitBH3-Interacting Domain Death Agonist (BID)UnconjugatedELISA, WB, IHC, FCM281.2580 µlP70444RUO
AbbexaBIDabx273988BH3 Interacting Domain Death Agonist (Bid) Antibody (FITC)MousePolyclonalRabbitBH3 Interacting Domain Death Agonist (Bid)FITCWB, IHC, IF/ICC375200 µlRUO
AbbexaBIDabx273194BH3 Interacting Domain Death Agonist (Bid) Antibody (Biotin)RatPolyclonalRabbitBH3 Interacting Domain Death Agonist (Bid)BiotinWB, IHC, IF/ICC362.5200 µlRUO
AbbexaBIDabx370067BH3 Interacting Domain Death Agonist (Bid) Antibody PairRatBH3 Interacting Domain Death Agonist (Bid)ELISA1437.55 × 96 testsRUO
AbbexaBIDabx171417BH3 Interacting Domain Death Agonist (Bid) AntibodyRatMonoclonalMouseBH3 Interacting Domain Death Agonist (Bid)UnconjugatedWB, IHC, IF/ICC275100 µlRUO
AbbexaBIDabx103692BH3 Interacting Domain Death Agonist (Bid) AntibodyRatPolyclonalRabbitBH3 Interacting Domain Death Agonist (Bid)UnconjugatedWB, IHC, IF/ICC262.5100 µlQ9JLT6RUO
AbbexaBIDabx274126BH3 Interacting Domain Death Agonist (Bid) Antibody (FITC)RatPolyclonalRabbitBH3 Interacting Domain Death Agonist (Bid)FITCWB, IHC, IF/ICC425200 µlRUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
AbbexaBIDabx693593Mouse BH3-Interacting Domain Death Agonist (BID) ProteinMouseRecombinantE. coliSDS-PAGE837.5100 µgRUO
AbbexaBIDabx262325BH3-Interacting Domain Death Agonist (BID) ProteinRecombinantUnconjugatedSDS-PAGE2252 µgP70444RUO
FineTestBIDP2186Recombinant Human BIDHumanRecombinantE.ColiWestern Blot, ELISA50μgP55957RUO
AbbexaBIDabx262316BH3-Interacting Domain Death Agonist (BID) ProteinRecombinantUnconjugatedSDS-PAGE2252 µgP70444RUO
AbbexaBIDabx065536Human BH3 Interacting Domain Death Agonist (Bid) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE187.510 µgP55957RUO
AbbexaBIDabx065538Rat BH3 Interacting Domain Death Agonist (Bid) ProteinRatRecombinantE. coliUnconjugatedWB, SDS-PAGE2162.51 mgQ9JLT6RUO
AbbexaBIDabx262975BH3-Interacting Domain Death Agonist (BID) ProteinRecombinantUnconjugatedSDS-PAGE2252 µgP55957RUO
AbbexaBIDabx065537Mouse BH3 Interacting Domain Death Agonist (Bid) ProteinMouseRecombinantE. coliUnconjugatedWB, SDS-PAGE2162.51 mgP70444RUO

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