Mouse BH3-Interacting Domain Death Agonist (BID) Protein (Active)
1079€ (100 µg)
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name
Mouse BH3-Interacting Domain Death Agonist (BID) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx693593
tested applications
SDS-PAGE
Description
Mouse BID Protein is a recombinant protein from Mouse produced in E. coli. A DNA sequence encoding the mature form of mouse BID (EDK99650.1) (Met 1-Asp 195) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | BID |
| Host | E. coli |
| Origin | Mouse |
| Observed MW | Molecular Weight: 50 kDa Sequence Fragment: Met1-Asp195 Tag: N-terminal His tag and GST tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 50mM Tris, 150mM NaCl, pH 7.5. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | EDK99650.1 |
| Alias | p22 BID,FP497 |
| Background | Protein BID |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
BH3-interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 family that plays a crucial role in the mitochondrial pathway of apoptosis BID contains a BH3 domain that enables it to interact with anti-apoptotic Bcl-2 family members, promoting apoptosis in response to various stress signals When activated, BID undergoes proteolytic cleavage, resulting in the generation of a truncated form, tBID, which translocates to the mitochondria and triggers the release of cytochrome c from the mitochondrial membrane This release activates the caspase cascade, leading to cell death BID is critical in the cellular response to DNA damage, oxidative stress, and death receptor signaling It also plays a role in immune cell homeostasis, particularly in regulating the survival of T-cells and the elimination of damaged or infected cells BID’s involvement in apoptosis has made it a significant focus in cancer research, where its activity can be modulated to promote tumor cell death Additionally, BID’s role in maintaining cellular integrity under stress underscores its importance in preventing disease progression and maintaining healthy tissue turnover
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