BH3-Interacting Domain Death Agonist (BID) Antibody

Este producto es parte de BID - BH3-interacting domain death agonist
Product Graph
364€ (100 µg)

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935106861
info@markelab.com
name
BH3-Interacting Domain Death Agonist (BID) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230893
tested applications
ELISA, WB

Description

BID Antibody is a Mouse Monoclonal against BID.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
BH3-Interacting Domain Death Agonist (BID)
Host
Mouse
Reactivity
Human
Recommended Dilution
WB: 1/2000 - 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG2a
Purity
≥ 95% (SDS-PAGE)
Purification
Purified by Protein A and Protein G affinity chromatography.
Size 1
100 µg
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P55957
Alias
p22 BID,FP497
Background
Antibody anti-BID
Status
RUO
Note
Concentration: 2 mg/ml - Validity: 12 months.

Descripción

BH3-interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 family that plays a crucial role in the mitochondrial pathway of apoptosis BID contains a BH3 domain that enables it to interact with anti-apoptotic Bcl-2 family members, promoting apoptosis in response to various stress signals When activated, BID undergoes proteolytic cleavage, resulting in the generation of a truncated form, tBID, which translocates to the mitochondria and triggers the release of cytochrome c from the mitochondrial membrane This release activates the caspase cascade, leading to cell death BID is critical in the cellular response to DNA damage, oxidative stress, and death receptor signaling It also plays a role in immune cell homeostasis, particularly in regulating the survival of T-cells and the elimination of damaged or infected cells BID’s involvement in apoptosis has made it a significant focus in cancer research, where its activity can be modulated to promote tumor cell death Additionally, BID’s role in maintaining cellular integrity under stress underscores its importance in preventing disease progression and maintaining healthy tissue turnover

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