BH3 Interacting Domain Death Agonist (Bid) Antibody (Biotin)

Este producto es parte de BID - BH3-interacting domain death agonist
Product Graph
325€ (200 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
BH3 Interacting Domain Death Agonist (Bid) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx272722
tested applications
WB, IHC, IF/ICC

Description

BH3 Interacting Domain Death Agonist (Bid) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against BH3 Interacting Domain Death Agonist (Bid).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
BH3 Interacting Domain Death Agonist (Bid)
Host
Rabbit
Reactivity
Mouse
Recommended Dilution
WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Biotin
Isotype
IgG
Purification
Purified by antigen-specific affinity chromatography.
Size 1
200 µl
Size 2
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
p22 BID,FP497
Background
Antibody anti-BID
Status
RUO

Descripción

BH3-interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 family that plays a crucial role in the mitochondrial pathway of apoptosis BID contains a BH3 domain that enables it to interact with anti-apoptotic Bcl-2 family members, promoting apoptosis in response to various stress signals When activated, BID undergoes proteolytic cleavage, resulting in the generation of a truncated form, tBID, which translocates to the mitochondria and triggers the release of cytochrome c from the mitochondrial membrane This release activates the caspase cascade, leading to cell death BID is critical in the cellular response to DNA damage, oxidative stress, and death receptor signaling It also plays a role in immune cell homeostasis, particularly in regulating the survival of T-cells and the elimination of damaged or infected cells BID’s involvement in apoptosis has made it a significant focus in cancer research, where its activity can be modulated to promote tumor cell death Additionally, BID’s role in maintaining cellular integrity under stress underscores its importance in preventing disease progression and maintaining healthy tissue turnover

Related Products

EH0983

Human BID (BH3-interacting domain death agonist) ELISA Kit

Ver Producto
EH4219

Human Cleaved BID/TBID (Cleaved BH3-interacting domain death agonist) ELISA Kit

Ver Producto
FNab00892

BID antibody

The major proteolytic product p15 BID allows the release of cytochrome c(By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.

Ver Producto