Mouse BH3 Interacting Domain Death Agonist (Bid) Protein

Este producto es parte de BID - BH3-interacting domain death agonist
Mouse BH3 Interacting Domain Death Agonist (Bid) Protein

Pida mas información

935106861

info@markelab.com

Precio

2249€ (1 mg)

Protein BID

proveedor

Abbexa

reference

abx065537

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant BH3 Interacting Domain Death Agonist (Bid) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

BH3-interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 family that plays a crucial role in the mitochondrial pathway of apoptosis BID contains a BH3 domain that enables it to interact with anti-apoptotic Bcl-2 family members, promoting apoptosis in response to various stress signals When activated, BID undergoes proteolytic cleavage, resulting in the generation of a truncated form, tBID, which translocates to the mitochondria and triggers the release of cytochrome c from the mitochondrial membrane This release activates the caspase cascade, leading to cell death BID is critical in the cellular response to DNA damage, oxidative stress, and death receptor signaling It also plays a role in immune cell homeostasis, particularly in regulating the survival of T-cells and the elimination of damaged or infected cells BID’s involvement in apoptosis has made it a significant focus in cancer research, where its activity can be modulated to promote tumor cell death Additionally, BID’s role in maintaining cellular integrity under stress underscores its importance in preventing disease progression and maintaining healthy tissue turnover

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

BH3 Interacting Domain Death Agonist (Bid)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

1 mg


size 2

5 mg


observerd MW

Molecular Weight: Calculated MW: 25.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Asp195 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

BID


dry ice

No


availability

Shipped within 1-2 months.


alias

p22 BID,FP497


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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