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Advanced glycation end products (AGEs) are a complex group of compounds that form through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. These reactions, known as glycation or Maillard reactions, occur spontaneously and accelerate under conditions of hyperglycemia (elevated blood sugar levels) and oxidative stress. AGEs accumulate in various tissues over time, particularly in long-lived proteins like collagen, and their formation is associated with aging and several chronic diseases, including diabetes, cardiovascular disease, Alzheimer's disease, and kidney disease. AGEs are formed through a series of chemical reactions between reducing sugars and proteins, lipids, or nucleic acids. These reactions result in the irreversible modification of biomolecules, leading to changes in their structure and function. AGEs accumulate in tissues over time, particularly in long-lived proteins such as collagen. This accumulation contributes to the pathogenesis of various age-related diseases. AGEs can cross-link with proteins, leading to the formation of advanced glycation end product-crosslinks (AGE-crosslinks). This cross-linking alters the structure and function of proteins and contributes to tissue stiffness and dysfunction. AGEs can also bind to cell surface receptors known as receptor for advanced glycation end products (RAGEs), activating signaling pathways that promote inflammation, oxidative stress, and tissue damage. AGEs can induce oxidative stress by generating reactive oxygen species (ROS) and impairing antioxidant defenses, leading to cellular damage and dysfunction. AGE accumulation and RAGE activation have been implicated in the pathogenesis of various diseases, including diabetes complications (e.g., nephropathy, retinopathy), cardiovascular disease (e.g., atherosclerosis), neurodegenerative diseases (e.g., Alzheimer's disease), and chronic kidney disease.
AGEs are diverse molecules resulting from the reaction between reducing sugars and the amino groups of proteins, lipids, or nucleic acids. Common structural features include:
AGEs can be classified based on their origin and chemical properties:
AGEs have significant biological effects due to their ability to modify proteins and interact with cellular receptors:
AGEs interact with various cellular components and influence multiple pathways:
The accumulation of AGEs is associated with various chronic diseases and aging:
Advanced Glycation End Products (AGEs) are harmful compounds formed through the non-enzymatic glycation of proteins, lipids, and nucleic acids. AGEs accumulate in tissues and contribute to aging and the pathogenesis of various chronic diseases, including diabetes, cardiovascular diseases, and neurodegenerative disorders. AGEs exert their effects by modifying proteins and interacting with cellular receptors such as RAGE, leading to inflammation, oxidative stress, and tissue damage. Understanding the role of AGEs in disease can inform strategies for prevention and treatment, highlighting the importance of managing blood sugar levels and reducing dietary intake of AGEs.
Advanced Glycation End Product (AGE)
AGE
Advanced Glycosylation End Product Specific Receptor (AGER)
RAGE,SCARJ1,sRAGE
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con AGE - Advanced Glycation End Product (Receptor)
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 55 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | AGER | abx518938 | Cow Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q28173 | RUO | ||
Abbexa | AGE | abx054078 | Advanced Glycation End Product (AGE) ELISA Kit | General | Serum,Plasma,Other biological fluids | Competitive | 15.6 ng/ml - 1000 ng/ml | 9.38 ng/ml | 556.25 | 96 tests | RUO | |
Abbexa | AGE | abx150316 | Advanced Glycation End Product (AGE) ELISA Kit | General | Serum,Plasma,Other biological fluids | Competitive | 98.8 ng/ml - 8000 ng/ml | < 38.2 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | AGE | abx490411 | Advanced Glycation End Product (AGE) CLIA Kit | General | Serum, plasma and other biological fluids. | Competitive | 98.8 ng/ml - 8000 ng/ml | < 38.2 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | AGE | abx576530 | Advanced Glycation End Product (AGE) ELISA Kit | General | Serum,Plasma,Other biological fluids | Competitive | 125 ng/ml - 8000 ng/ml | 75 ng/ml | 556.25 | 96 tests | RUO | |
FineTest | AGE | EH0622 | Human AGE(Advanced glycation end-product) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.313-20ng/ml | 96T | P51606 | RUO | ||
Abbexa | AGE | abx054077 | Human Advanced Glycation End Product (AGE) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Competitive | 19.75 ng/ml - 1600 ng/ml | < 7.13 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | AGER | abx491820 | Human Advanced Glycosylation End Product-Specific Receptor (AGER) CLIA Kit | Human | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.059 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | AGER | abx150586 | Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | AGER | abx253583 | Human Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 46.9 pg/ml | 525 | 96 tests | RUO | |
Abbexa | AGER | abx196212 | Human Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 618.75 | 96 tests | RUO | |
FineTest | AGE | EM0716 | Mouse AGE(Mouse advanced glycation end product) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | RUO | |||
Abbexa | AGER | abx254878 | Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 31.25 pg/ml - 2000 pg/ml | 18.75 pg/ml | 525 | 96 tests | RUO | |
Abbexa | AGER | abx190466 | Mouse Advanced Glycosylation End Product-Specific Receptor (AGER) CLIA Kit | Mouse | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 13.7 pg/ml - 10000 pg/ml | < 4.4 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | AGER | abx570606 | Low Sample Volume Mouse Advanced Glycosylation End Product-Specific Receptor (AGER) ELISA Kit | Mouse | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 0.78 ng/ml - 50 ng/ml | 0.47 ng/ml | 612.5 | 96 tests | Q62151 | RUO |
Abbexa | AGER | abx153607 | Mouse Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 12.9 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | AGER | abx196213 | Mouse Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit | Mouse | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 618.75 | 96 tests | RUO | |
FineTest | AGE | ER0268 | Rat AGE(Advanced glycation end-product) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.313-20ng/ml | 96T | P51607 | RUO | ||
Abbexa | AGER | abx156891 | Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 675 | 96 tests | RUO | |
Abbexa | AGER | abx256697 | Rat Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 562.5 | 96 tests | Q63495 | RUO |
Abbexa | AGER | abx196214 | Rat Advanced Glycosylation End Product Specific Receptor (AGER) CLIA Kit | Rat | Serum, plasma and other biological fluids. | Sandwich | 12.5 pg/ml - 800 pg/ml | 7.5 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | AGER | abx491821 | Rat Advanced Glycosylation End Product-Specific Receptor (AGER) CLIA Kit | Rat | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.055 ng/ml | 812.5 | 96 tests | RUO | |
FineTest | AGE | EU0406 | AGE(Advanced glycation end-product) ELISA Kit | universal | Busacar en las instrucciones | Competitive ELISA, Coated with Antigen | 62.5-4000ng/ml | 96T | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | AGE | abx102967 | Advanced Glycation End Product (AGE) Antibody | General | Polyclonal | Rabbit | Advanced Glycation End Product (AGE) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO | ||
Abbexa | AGE | abx131709 | Advanced Glycation End Product (AGE) Antibody | General | Monoclonal | Mouse | Advanced Glycation End Product (AGE) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO | ||
FineTest | AGER | FNab00209 | anti- AGER antibody | human | polyclonal | Rabbit | advanced glycosylation end product-specific receptor | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q15109 | RUO | |
FineTest | AGER | FNab10403 | anti- AGER antibody | human | polyclonal | Rabbit | advanced glycosylation end product-specific receptor | IgG | Unconjugated | ELISA, WB, IHC | 100µg | Q15109 | RUO | |
FineTest | AGER | FNab09951 | anti- AGER antibody | human | monoclonal | Mouse | advanced glycosylation end product-specific receptor | IgG1 | Unconjugated | ELISA, WB | 100µg | Q15109 | RUO | |
Abbexa | AGER | abx211206 | Advanced Glycosylation End Product-Specific Receptor (AGER) Antibody | Human | Polyclonal | Rabbit | Advanced Glycosylation End Product-Specific Receptor (AGER) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q15109 | RUO | |
Abbexa | AGER | abx106525 | Advanced Glycosylation End Product-Specific Receptor (AGER) Antibody (FITC) | Human | Polyclonal | Rabbit | Advanced Glycosylation End Product-Specific Receptor (AGER) | FITC | 162.5 | 20 µg | Q15109 | RUO | ||
Abbexa | AGER | abx107942 | Advanced Glycosylation End Product-Specific Receptor (AGER) Antibody (HRP) | Human | Polyclonal | Rabbit | Advanced Glycosylation End Product-Specific Receptor (AGER) | HRP | ELISA | 162.5 | 20 µg | Q15109 | RUO | |
Abbexa | AGER | abx036573 | Advanced Glycosylation End Product Specific Receptor (AGER) Antibody | Human | Polyclonal | Rabbit | Advanced Glycosylation End Product Specific Receptor (AGER) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | AGER | abx171123 | Advanced Glycosylation End Product Specific Receptor (AGER) Antibody | Human | Monoclonal | Mouse | Advanced Glycosylation End Product Specific Receptor (AGER) | Unconjugated | WB, IHC, IF/ICC | 712.5 | 1 ml | RUO | ||
Abbexa | AGER | abx104577 | Advanced Glycosylation End Product Specific Receptor (AGER) Antibody | Human | Polyclonal | Rabbit | Advanced Glycosylation End Product Specific Receptor (AGER) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | Q15109 | RUO | |
Abbexa | AGER | abx105108 | Advanced Glycosylation End Product-Specific Receptor (AGER) Antibody (Biotin) | Human | Polyclonal | Rabbit | Advanced Glycosylation End Product-Specific Receptor (AGER) | Biotin | ELISA | 162.5 | 20 µg | Q15109 | RUO | |
Abbexa | AGER | abx109506 | Advanced Glycosylation End Product-Specific Receptor (AGER) Antibody | Human | Polyclonal | Rabbit | Advanced Glycosylation End Product-Specific Receptor (AGER) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q15109 | RUO | |
Abbexa | AGER | abx324550 | Advanced Glycosylation End Product-Specific Receptor (AGER) Antibody | Human | Polyclonal | Rabbit | Advanced Glycosylation End Product-Specific Receptor (AGER) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | Q15109 | RUO | |
Abbexa | AGER | abx211205 | Advanced Glycosylation End Product-Specific Receptor (AGER) Antibody | Human | Polyclonal | Rabbit | Advanced Glycosylation End Product-Specific Receptor (AGER) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q15109 | RUO | |
Abbexa | AGER | abx032323 | Advanced Glycosylation End Product-Specific Receptor (AGER) Antibody | Human | Polyclonal | Rabbit | Advanced Glycosylation End Product-Specific Receptor (AGER) | Unconjugated | ELISA, WB, IHC, FCM | 250 | 80 µl | Q15109 | RUO | |
Abbexa | AGER | abx001218 | Advanced Glycosylation End Product-Specific Receptor (AGER) Antibody | Human | Polyclonal | Rabbit | Advanced Glycosylation End Product-Specific Receptor (AGER) | Unconjugated | WB | 175 | 20 µl | Q15109 | RUO | |
Abbexa | AGER | abx230209 | Advanced Glycosylation End Product Specific Receptor (AGER) Antibody | Human | Polyclonal | Rabbit | Advanced Glycosylation End Product Specific Receptor (AGER) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q15109 | RUO | |
Abbexa | AGER | abx020069 | Advanced Glycosylation End Product-Specific Receptor (AGER) Antibody | Human | Polyclonal | Rabbit | Advanced Glycosylation End Product-Specific Receptor (AGER) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | Q15109 | RUO | |
Abbexa | AGER | abx239942 | Advanced Glycosylation End Product-Specific Receptor (AGER) Antibody | Human | Monoclonal | Mouse | Advanced Glycosylation End Product-Specific Receptor (AGER) | Unconjugated | ELISA, WB | 350 | 100 µg | Q15109 | RUO | |
Abbexa | AGER | abx104578 | Advanced Glycosylation End Product Specific Receptor (AGER) Antibody | Mouse | Polyclonal | Rabbit | Advanced Glycosylation End Product Specific Receptor (AGER) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q62151 | RUO | |
Abbexa | AGER | abx130064 | Advanced Glycosylation End Product Specific Receptor (AGER) Antibody | Rat | Polyclonal | Rabbit | Advanced Glycosylation End Product Specific Receptor (AGER) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q63495 | RUO | |
Abbexa | AGER | abx370664 | Advanced Glycosylation End Product Specific Receptor (AGER) Antibody Pair | Rat | Advanced Glycosylation End Product Specific Receptor (AGER) | ELISA | 1437.5 | 5 × 96 tests | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | AGE | abx168580 | Advanced Glycation End Product (AGE) Protein | General | Native | Unconjugated | WB, SDS-PAGE | 300 | 50 µg | RUO | ||
Abbexa | AGE | abx651294 | Cow Advanced Glycation End Product (AGE) Protein (Active) | Cow | Native | Cow | Unconjugated | SDS-PAGE | 375 | 50 µg | RUO | |
Abbexa | AGER | abx168527 | Rat Advanced Glycosylation End Product Specific Receptor (AGER) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | AGER | abx065184 | Human Advanced Glycosylation End Product Specific Receptor (AGER) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 237.5 | 10 µg | Q15109 | RUO |
Abbexa | AGER | abx065185 | Mouse Advanced Glycosylation End Product Specific Receptor (AGER) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | Q62151 | RUO |
Abbexa | AGER | abx694214 | Human Advanced Glycosylation End Product-Specific Receptor (AGER) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 400 | 20 µg | Q15109 | RUO | |
Abbexa | AGER | abx680020 | Human Advanced Glycosylation End Product-Specific Receptor (AGER) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 2 µg | RUO | |
FineTest | AGER | P0529 | Recombinant Human AGER | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | Q15109 | RUO | ||
Abbexa | AGER | abx694299 | Rat Advanced Glycosylation End Product-Specific Receptor (AGER) Protein | Rat | Recombinant | HEK293 cells | SDS-PAGE | 300 | 20 µg | Q63495 | RUO |
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