Human Advanced Glycation End Product (AGE) Protein
312€ (50 µg)
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name
Human Advanced Glycation End Product (AGE) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168580
tested applications
WB, SDS-PAGE
Description
Advanced Glycation End Products (AGEs) are the result of a chain of chemical reactions after an initial glycation reaction. Glycation is accomplished by the Maillard reaction, which is a multistep process that begins with Schiff base formation between the amine and the carbonyl group on the sugar followed by rearrangement to form Amadori intermediates. AGEs affect nearly every type of cell and molecule in the body, and are thought to be one factor in aging and some age-related chronic diseases. They are also believed to play a causative role in the vascular complications of diabetes mellitus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Advanced Glycation End Product (AGE) |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 10 mg/ml |
| Expression | Native |
| Purity | > 90% (SDS-PAGE) |
| Purification | Purified by salt co-precipitation and ion exchange chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 500 µg |
| Size 5 | 1 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AGE |
| Background | Protein AGE |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Advanced Glycation End Products (AGEs) are a diverse group of molecules formed through the non-enzymatic reaction of reducing sugars with proteins, lipids, or nucleic acids in a process called glycation. AGEs accumulate under conditions of oxidative stress and hyperglycemia, particularly in diseases like diabetes mellitus, where they are formed in excess. They are commonly found in long-lived proteins such as collagen and elastin, contributing to tissue stiffness and organ dysfunction. AGEs can crosslink proteins, disrupt cellular signaling, and impair extracellular matrix structure. They are also known to interact with specific receptors, such as the AGE receptor (AGER), activating inflammatory and oxidative pathways that lead to chronic conditions such as cardiovascular disease, kidney damage, and neurodegeneration. AGEs are considered major contributors to aging and the progression of age-related diseases, making them significant biomarkers and therapeutic targets.
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