Advanced Glycation End Product (AGE) Antibody
299€ (100 µl)
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Name
Advanced Glycation End Product (AGE) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx131709
Tested Applications
WB, IHC, IF/ICC
Description
Advanced Glycation End Product (AGE) Antibody is a Mouse Monoclonal against Advanced Glycation End Product (AGE).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Advanced Glycation End Product (AGE) Immunogen: abx168580 - Native AGE Protein. |
| Host | Mouse |
| Reactivity | General |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a Kappa |
| Clone ID | T453 |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AGE |
| Background | Antibody anti-AGE |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Advanced Glycation End Products (AGEs) are a diverse group of molecules formed through the non-enzymatic reaction of reducing sugars with proteins, lipids, or nucleic acids in a process called glycation. AGEs accumulate under conditions of oxidative stress and hyperglycemia, particularly in diseases like diabetes mellitus, where they are formed in excess. They are commonly found in long-lived proteins such as collagen and elastin, contributing to tissue stiffness and organ dysfunction. AGEs can crosslink proteins, disrupt cellular signaling, and impair extracellular matrix structure. They are also known to interact with specific receptors, such as the AGE receptor (AGER), activating inflammatory and oxidative pathways that lead to chronic conditions such as cardiovascular disease, kidney damage, and neurodegeneration. AGEs are considered major contributors to aging and the progression of age-related diseases, making them significant biomarkers and therapeutic targets.
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