Cow Advanced Glycation End Product (AGE) Protein (Active)
390€ (50 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Cow Advanced Glycation End Product (AGE) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx651294
tested applications
SDS-PAGE
Description
Advanced Glycation End Product (AGE) Protein (Active) is an active Cow Protein prepared by glycosylation of extracted Bovine Serum Albumin (BSA), catalyzed by CuSO
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Advanced Glycation End Product (AGE) |
| Host | Cow |
| Origin | Cow |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 2000 µg/ml |
| Expression | Native |
| Purity | > 90% (SDS-PAGE) |
| Purification | Purified by salt co-precipitation and ion-exchange chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 1 mg |
| Size 5 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 10 mM PBS, pH 7.4, containing 5% Trehalose. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AGE |
| Background | Protein AGE |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Advanced Glycation End Products (AGEs) are a diverse group of molecules formed through the non-enzymatic reaction of reducing sugars with proteins, lipids, or nucleic acids in a process called glycation. AGEs accumulate under conditions of oxidative stress and hyperglycemia, particularly in diseases like diabetes mellitus, where they are formed in excess. They are commonly found in long-lived proteins such as collagen and elastin, contributing to tissue stiffness and organ dysfunction. AGEs can crosslink proteins, disrupt cellular signaling, and impair extracellular matrix structure. They are also known to interact with specific receptors, such as the AGE receptor (AGER), activating inflammatory and oxidative pathways that lead to chronic conditions such as cardiovascular disease, kidney damage, and neurodegeneration. AGEs are considered major contributors to aging and the progression of age-related diseases, making them significant biomarkers and therapeutic targets.
Related Products
Human AGE(Advanced glycation end-product) ELISA Kit
Ver Producto
Mouse AGE(Mouse advanced glycation end product) ELISA Kit
Ver Producto