Advanced Glycosylation End Product-Specific Receptor (AGER) Antibody

Este producto es parte de AGE - Advanced Glycation End Product (Receptor)
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169€ (20 µg)

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935106861
info@markelab.com
name
Advanced Glycosylation End Product-Specific Receptor (AGER) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx109506
tested applications
ELISA, IHC, IF/ICC

Description

Advanced glycosylation end product-specific receptor Antibody is a Rabbit Polyclonal antibody against Advanced glycosylation end product-specific receptor.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetAdvanced Glycosylation End Product-Specific Receptor (AGER)
HostRabbit
ReactivityHuman
Recommended DilutionIHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
Purity> 95%
PurificationPurified by Protein G.
Size 120 µg
Size 250 µg
Size 3100 µg
Size 4200 µg
Size 51 mg
FormLiquid
Tested ApplicationsELISA, IHC, IF/ICC
Buffer0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDQ15109
Gene ID177
NCBI AccessionNP_001127.1, NM_001136.4
OMIM600214
AliasRAGE,SCARJ1,sRAGE
BackgroundAntibody anti-AGER
StatusRUO

Descripción

AGER, also known as RAGE (Receptor for Advanced Glycation End Products), is a transmembrane receptor belonging to the immunoglobulin superfamily that binds to AGEs and other ligands such as S100 proteins, HMGB1, and amyloid-β. AGER is widely expressed, particularly in the endothelium, lungs, brain, and immune cells, and plays a critical role in inflammatory and oxidative stress signaling. Binding of AGEs to AGER activates downstream pathways, including NF-κB, MAPK, and JAK/STAT, leading to the production of pro-inflammatory cytokines and reactive oxygen species. Overexpression or chronic activation of AGER is associated with diseases such as diabetes complications, atherosclerosis, Alzheimer’s disease, and cancer, where it exacerbates inflammation and tissue damage. AGER is a promising therapeutic target for reducing AGE-mediated pathologies and modulating immune and metabolic dysfunction.

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