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Hexosaminidase A (alpha polypeptide), also known as HEXA, corresponds to an enzyme encoded by the HEXA gene in humans. However, it's important to note that there is a chromosomal difference between humans and mice, with the HEXA gene located on chromosome 9 in humans and chromosome 15 in mice.The primary function of Hexosaminidase A, along with the cofactor GM2 activator protein, is to facilitate the degradation of GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines.The HEXA gene in humans spans approximately 26 kb and is composed of 14 exons and 13 introns. In conjunction with the HEXB gene, which encodes the beta-subunit, these genes collectively produce human beta-hexosaminidase, with HEXA responsible for the alpha-subunit. In mice, the equivalent genes are termed Hexa and Hexb.The subunits of beta-hexosaminidase, when they come together, form three distinct isozymes: beta-hexosaminidase A (alpha beta), beta-hexosaminidase B (beta beta), and beta-hexosaminidase S (alpha alpha). These isozymes possess the capability to break down various substrates that contain beta-linked N-acetylglucosamine and N-acetylgalactosamine residues.
Beta-hexosaminidase A is a heterodimer composed of an alpha subunit (encoded by HEXA) and a beta subunit (encoded by HEXB). The mature alpha subunit has 529 amino acids and includes several glycosylation sites that are important for its stability and function. The enzyme's structure allows it to bind and hydrolyze GM2 gangliosides efficiently within the lysosome.
Beta-hexosaminidase A is one of three isoenzymes:
The HEXA gene encodes the alpha subunit of beta-hexosaminidase A, an enzyme critical for the degradation of GM2 gangliosides in lysosomes. Mutations in HEXA lead to Tay-Sachs disease, a severe neurodegenerative disorder characterized by the accumulation of GM2 gangliosides in neurons. Understanding the structure, function, and interactions of Hex A is crucial for diagnosing, managing, and potentially developing treatments for Tay-Sachs disease. Carrier screening programs have significantly impacted the incidence of this disease in high-risk populations.
Hexosaminidase subunit alpha (HEXA)
N-acetyl-beta-glucosaminidase subunit alpha,TSD
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con HEXA - Beta-Hexosaminidase Subunit Alpha
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 33 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | HEXA | abx512150 | Cow Beta-Hexosaminidase Subunit Alpha (HEXA) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q0V8R6 | RUO | ||
Abbexa | HEXA | abx526928 | Human Putative uncharacterized protein encoded by HEXA-AS1 (HEXA-AS1) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9H8Q6 | RUO | ||
Abbexa | HEXA | abx151799 | Human Hexosaminidase A alpha (HEXa) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | HEXA | abx491208 | Human Hexosaminidase A alpha (HEXa) CLIA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.063 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | HEXA | abx154135 | Mouse Hexosaminidase A alpha (HEXa) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | HEXA | abx051224 | Mouse Beta-Hexosaminidase Subunit Alpha (HEXA) ELISA Kit | Mouse | Serum,Plasma,Other biological fluids | Sandwich | 15.63 pg/ml - 1000 pg/ml | 9.38 pg/ml | 562.5 | 96 tests | RUO | |
Abbexa | HEXA | abx254518 | Mouse Beta-Hexosaminidase Subunit Alpha (HEXA) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 525 | 96 tests | P29416 | RUO |
Abbexa | HEXA | abx491209 | Mouse Hexosaminidase A alpha (HEXa) CLIA Kit | Mouse | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.059 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | HEXA | abx256113 | Rat Beta-Hexosaminidase Subunit Alpha (HEXA) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 531.25 | 96 tests | Q641X3 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | HEXA | FNab03843 | anti- HEXA antibody | human | monoclonal | Mouse | hexosaminidase A(alpha polypeptide) | IgG2a | Unconjugated | ELISA, WB | 100µg | P06865 | RUO | |
FineTest | HEXA | FNab03842 | anti- HEXA antibody | human | polyclonal | Rabbit | hexosaminidase A (alpha polypeptide) | IgG | Unconjugated | ELISA, WB, IHC | 100µg | P06865 | RUO | |
Abbexa | HEXA | abx033085 | Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody | Human | Polyclonal | Rabbit | Beta-Hexosaminidase Subunit Alpha (HEXA) | Unconjugated | ELISA, WB, IHC, FCM | 281.25 | 80 µl | P06865 | RUO | |
Abbexa | HEXA | abx137331 | Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody | Human | Monoclonal | Mouse | Beta-Hexosaminidase Subunit Alpha (HEXA) | Unconjugated | 225 | 5 µg | RUO | |||
Abbexa | HEXA | abx172802 | Hexosaminidase A Alpha (HEXa) Antibody | Human | Monoclonal | Mouse | Hexosaminidase A Alpha (HEXa) | Unconjugated | WB, IHC, IF/ICC | 712.5 | 1 ml | RUO | ||
Abbexa | HEXA | abx233843 | Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody | Human | Monoclonal | Mouse | Beta-Hexosaminidase Subunit Alpha (HEXA) | Unconjugated | ELISA, WB | 350 | 100 µg | P06865 | RUO | |
Abbexa | HEXA | abx334833 | Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody (HRP) | Human | Polyclonal | Rabbit | Beta-Hexosaminidase Subunit Alpha (HEXA) | HRP | ELISA | 162.5 | 20 µg | P06865 | RUO | |
Abbexa | HEXA | abx334835 | Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody (Biotin) | Human | Polyclonal | Rabbit | Beta-Hexosaminidase Subunit Alpha (HEXA) | Biotin | ELISA | 162.5 | 20 µg | P06865 | RUO | |
Abbexa | HEXA | abx334834 | Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody (FITC) | Human | Polyclonal | Rabbit | Beta-Hexosaminidase Subunit Alpha (HEXA) | FITC | 162.5 | 20 µg | P06865 | RUO | ||
Abbexa | HEXA | abx128676 | Hexosaminidase A Alpha (HEXa) Antibody | Human | Polyclonal | Rabbit | Hexosaminidase A Alpha (HEXa) | Unconjugated | WB, IHC, IF/ICC | 250 | 100 µl | P06865 | RUO | |
Abbexa | HEXA | abx015883 | Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody | Human | Monoclonal | Mouse | Beta-Hexosaminidase Subunit Alpha (HEXA) | Unconjugated | ELISA, WB, FCM | 50 | 15 µg | RUO | ||
Abbexa | HEXA | abx146346 | Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody | Human | Polyclonal | Rabbit | Beta-Hexosaminidase Subunit Alpha (HEXA) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | HEXA | abx033084 | Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody | Human | Polyclonal | Rabbit | Beta-Hexosaminidase Subunit Alpha (HEXA) | Unconjugated | ELISA, WB, IHC, FCM | 281.25 | 80 µl | P06865 | RUO | |
Abbexa | HEXA | abx004317 | Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody | Human | Polyclonal | Rabbit | Beta-Hexosaminidase Subunit Alpha (HEXA) | Unconjugated | WB | 175 | 20 µl | P06865 | RUO | |
Abbexa | HEXA | abx113001 | Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody | Human | Polyclonal | Rabbit | Beta-Hexosaminidase Subunit Alpha (HEXA) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | P06865 | RUO | |
Abbexa | HEXA | abx327573 | Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody | Human | Polyclonal | Rabbit | Beta-Hexosaminidase Subunit Alpha (HEXA) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P06865 | RUO | |
Abbexa | HEXA | abx233842 | Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody | Human | Polyclonal | Rabbit | Beta-Hexosaminidase Subunit Alpha (HEXA) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | P06865 | RUO | |
Abbexa | HEXA | abx338674 | Beta-Hexosaminidase Subunit Alpha (HEXA) Antibody | Human | Polyclonal | Rabbit | Beta-Hexosaminidase Subunit Alpha (HEXA) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | P06865 | RUO | |
Abbexa | HEXA | abx102257 | Hexosaminidase A Alpha (HEXa) Antibody | Mouse | Polyclonal | Rabbit | Hexosaminidase A Alpha (HEXa) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P29416 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | HEXA | abx067092 | Mouse Hexosaminidase A Alpha (HEXa) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P29416 | RUO |
Abbexa | HEXA | abx651347 | Mouse Hexosaminidase A Alpha (HEXa) Protein (Active) | Mouse | E. coli | Unconjugated | WB, SDS-PAGE | 662.5 | 50 µg | P29416 | RUO | |
Abbexa | HEXA | abx166845 | Human Hexosaminidase A Alpha (HEXa) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P06865 | RUO |
Abbexa | HEXA | abx691409 | Human Beta-Hexosaminidase Subunit Alpha (HEXA) Protein | Human | Recombinant | Insect | SDS-PAGE | 1087.5 | 50 µg | RUO | ||
Abbexa | HEXA | abx073383 | Human Beta-Hexosaminidase Subunit Alpha (HEXA) Protein | Human | Recombinant | E. coli | SDS-PAGE | 225 | 5 µg | P06865 | RUO |
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