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Hexosaminidase A Alpha (HEXa) Antibody
proveedor
Abbexareference
abx172802Tested Applications
WB, IHC, IF/ICCreactivity
Humanstatus
RUOclonality
MonoclonalDescripción
This product is currently in development. The lead time for this product may be several months. Please contact us at info@markelab.com for an updated lead time before purchasing this product. Hexosaminidase A Alpha (HEXa) Antibody is a Mouse Monoclonal antibody against Hexosaminidase A Alpha (HEXa).
Background
Hexosaminidase A (alpha polypeptide), also known as HEXA, corresponds to an enzyme encoded by the HEXA gene in humans. However, it's important to note that there is a chromosomal difference between humans and mice, with the HEXA gene located on chromosome 9 in humans and chromosome 15 in mice.The primary function of Hexosaminidase A, along with the cofactor GM2 activator protein, is to facilitate the degradation of GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines.The HEXA gene in humans spans approximately 26 kb and is composed of 14 exons and 13 introns. In conjunction with the HEXB gene, which encodes the beta-subunit, these genes collectively produce human beta-hexosaminidase, with HEXA responsible for the alpha-subunit. In mice, the equivalent genes are termed Hexa and Hexb.The subunits of beta-hexosaminidase, when they come together, form three distinct isozymes: beta-hexosaminidase A (alpha beta), beta-hexosaminidase B (beta beta), and beta-hexosaminidase S (alpha alpha). These isozymes possess the capability to break down various substrates that contain beta-linked N-acetylglucosamine and N-acetylgalactosamine residues.
Background
La hexosaminidasa A (polipéptido alfa), también conocida como HEXA, corresponde a una enzima codificada por el gen HEXA en humanos. Sin embargo, es importante tener en cuenta que existe una diferencia cromosómica entre humanos y ratones, con el gen HEXA ubicado en el cromosoma 9 en humanos y en el cromosoma 15 en ratones. La función principal de la hexosaminidasa A, junto con la proteína activadora cofactor GM2, es facilitar la degradación de los gangliósidos GM2 y otras moléculas que contienen N-acetil hexosaminas terminales. El gen HEXA en humanos abarca aproximadamente 26 kb y está compuesto por 14 exones y 13 intrones. Junto con el gen HEXB, que codifica la subunidad beta, estos genes producen colectivamente la beta-hexosaminidasa humana, siendo HEXA responsable de la subunidad alfa. En ratones, los genes equivalentes se denominan Hexa y Hexb. Las subunidades de la beta-hexosaminidasa, cuando se unen, forman tres isoenzimas distintas: beta-hexosaminidasa A (alfa beta), beta-hexosaminidasa B (beta beta) y beta- hexosaminidasa S (alfa alfa). Estas isoenzimas poseen la capacidad de descomponer varios sustratos que contienen residuos de N-acetilglucosamina y N-acetilgalactosamina con enlaces beta.
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human
immunogen target
Hexosaminidase A Alpha (HEXa)
host
Mouse
conjugation
Unconjugated
form
Liquid
tested applications
WB, IHC, IF/ICC
purification
Purified by Protein A and Protein G affinity chromatography.
buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
size 1
1 ml
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
HEXA
dry ice
No
availability
Please enquire.
alias
N-acetyl-beta-glucosaminidase subunit alpha,TSD
note
This product is for research use only.
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