Human Beta-Hexosaminidase Subunit Alpha (HEXA) Protein

Background

Hexosaminidase A (alpha polypeptide), also known as HEXA, corresponds to an enzyme encoded by the HEXA gene in humans. However, it's important to note that there is a chromosomal difference between humans and mice, with the HEXA gene located on chromosome 9 in humans and chromosome 15 in mice.The primary function of Hexosaminidase A, along with the cofactor GM2 activator protein, is to facilitate the degradation of GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines.The HEXA gene in humans spans approximately 26 kb and is composed of 14 exons and 13 introns. In conjunction with the HEXB gene, which encodes the beta-subunit, these genes collectively produce human beta-hexosaminidase, with HEXA responsible for the alpha-subunit. In mice, the equivalent genes are termed Hexa and Hexb.The subunits of beta-hexosaminidase, when they come together, form three distinct isozymes: beta-hexosaminidase A (alpha beta), beta-hexosaminidase B (beta beta), and beta-hexosaminidase S (alpha alpha). These isozymes possess the capability to break down various substrates that contain beta-linked N-acetylglucosamine and N-acetylgalactosamine residues.

Características del producto

origin

Human

host

E. coli

immunogen target

Beta-Hexosaminidase Subunit Alpha (HEXA)

host

E. coli

form

Liquid

tested applications

SDS-PAGE

size 1

5 µg

size 2

20 µg

size 3

1 mg

expression

Recombinant

purity

> 85% (SDS-PAGE)

storage

Store at 4 °C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.

or code

HEXA

dry ice

availability

Shipped within 5-10 working days.

alias

N-acetyl-beta-glucosaminidase subunit alpha,TSD

uniprot id

https://www.uniprot.org/uniprotkb/P06865

note

This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.

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proveedor

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reference

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Tested Applications

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reactivity

human,mouse,rat

status

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clonality

polyclonal

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proveedor

Abbexa

reference

abx254518

Tested Applications

ELISA

reactivity

Mouse

status

RUO

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