Human Hexosaminidase A Protein is a recombinant protein from Human produced in Baculovirus-Insect Cells. A DNA sequence encoding the human HEXA (AAD13932.1) (Met 1-Thr 529) was fused with a polyhistidine tag at the C-terminus.
Hexosaminidase A (alpha polypeptide), also known as HEXA, corresponds to an enzyme encoded by the HEXA gene in humans. However, it's important to note that there is a chromosomal difference between humans and mice, with the HEXA gene located on chromosome 9 in humans and chromosome 15 in mice.The primary function of Hexosaminidase A, along with the cofactor GM2 activator protein, is to facilitate the degradation of GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines.The HEXA gene in humans spans approximately 26 kb and is composed of 14 exons and 13 introns. In conjunction with the HEXB gene, which encodes the beta-subunit, these genes collectively produce human beta-hexosaminidase, with HEXA responsible for the alpha-subunit. In mice, the equivalent genes are termed Hexa and Hexb.The subunits of beta-hexosaminidase, when they come together, form three distinct isozymes: beta-hexosaminidase A (alpha beta), beta-hexosaminidase B (beta beta), and beta-hexosaminidase S (alpha alpha). These isozymes possess the capability to break down various substrates that contain beta-linked N-acetylglucosamine and N-acetylgalactosamine residues.
Proteins and Peptides
Human
Insect
Hexosaminidase A
Insect
SDS-PAGE
50 µg
Recombinant
> 95% (SDS-PAGE)
Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4.
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
HEXA
No
Shipped within 5-15 working days.
N-acetyl-beta-glucosaminidase subunit alpha,TSD
AAD13932.1
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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