Rat Beta-Hexosaminidase Subunit Alpha (HEXA) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat beta hexosaminidase A concentrations in tissue homogenates, cell lysates and other biological fluids.
Hexosaminidase A (alpha polypeptide), also known as HEXA, corresponds to an enzyme encoded by the HEXA gene in humans. However, it's important to note that there is a chromosomal difference between humans and mice, with the HEXA gene located on chromosome 9 in humans and chromosome 15 in mice.The primary function of Hexosaminidase A, along with the cofactor GM2 activator protein, is to facilitate the degradation of GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines.The HEXA gene in humans spans approximately 26 kb and is composed of 14 exons and 13 introns. In conjunction with the HEXB gene, which encodes the beta-subunit, these genes collectively produce human beta-hexosaminidase, with HEXA responsible for the alpha-subunit. In mice, the equivalent genes are termed Hexa and Hexb.The subunits of beta-hexosaminidase, when they come together, form three distinct isozymes: beta-hexosaminidase A (alpha beta), beta-hexosaminidase B (beta beta), and beta-hexosaminidase S (alpha alpha). These isozymes possess the capability to break down various substrates that contain beta-linked N-acetylglucosamine and N-acetylgalactosamine residues.
La hexosaminidasa A (polipéptido alfa), también conocida como HEXA, corresponde a una enzima codificada por el gen HEXA en humanos. Sin embargo, es importante tener en cuenta que existe una diferencia cromosómica entre humanos y ratones, con el gen HEXA ubicado en el cromosoma 9 en humanos y en el cromosoma 15 en ratones. La función principal de la hexosaminidasa A, junto con la proteína activadora cofactor GM2, es facilitar la degradación de los gangliósidos GM2 y otras moléculas que contienen N-acetil hexosaminas terminales. El gen HEXA en humanos abarca aproximadamente 26 kb y está compuesto por 14 exones y 13 intrones. Junto con el gen HEXB, que codifica la subunidad beta, estos genes producen colectivamente la beta-hexosaminidasa humana, siendo HEXA responsable de la subunidad alfa. En ratones, los genes equivalentes se denominan Hexa y Hexb. Las subunidades de la beta-hexosaminidasa, cuando se unen, forman tres isoenzimas distintas: beta-hexosaminidasa A (alfa beta), beta-hexosaminidasa B (beta beta) y beta- hexosaminidasa S (alfa alfa). Estas isoenzimas poseen la capacidad de descomponer varios sustratos que contienen residuos de N-acetilglucosamina y N-acetilgalactosamina con enlaces beta.
ELISA Kits
Beta-Hexosaminidase Subunit Alpha (HEXA)
Rat
0.312 ng/ml - 20 ng/ml
0.19 ng/ml
Sandwich
Quantitative
Colorimetric
Tissue homogenates,Cell lysates,Other biological fluids
96 tests
N-acetyl-beta-glucosaminidase subunit alpha,TSD
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
HEXA
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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