Mouse Hexosaminidase A Alpha (HEXa) Protein
741€ (50 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Mouse Hexosaminidase A Alpha (HEXa) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx651347
tested applications
WB, SDS-PAGE
Description
Hexosaminidase A Alpha (HEXa) Protein (Active) is an active protein from Mouse.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Hexosaminidase A Alpha (HEXa) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 28.2 kDa Observed MW: 28 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu319-Thr528 Tag: N-terminal His tag |
| Purity | > 97% |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 500 µg |
| Size 5 | 1 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29416 |
| Alias | N-acetyl-beta-glucosaminidase subunit alpha,TSD |
| Background | Protein HEXA |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
HEXA is the alpha subunit of the beta-hexosaminidase enzyme, a lysosomal hydrolase that catalyzes the breakdown of GM2 gangliosides into GM3 in the process of glycosphingolipid degradation The enzyme functions as a heterodimer composed of alpha and beta subunits, encoded by the HEXA and HEXB genes respectively Mutations in HEXA lead to Tay-Sachs disease, an autosomal recessive lysosomal storage disorder characterized by the accumulation of GM2 gangliosides in neuronal cells, resulting in neurodegeneration, progressive motor weakness, and developmental delay HEXA is highly active in neuronal tissues where glycosphingolipid metabolism is critical for normal brain function The absence or dysfunction of HEXA causes a loss of enzymatic activity leading to cellular toxicity and apoptosis Current therapeutic approaches include enzyme replacement therapy, substrate reduction therapy, and gene therapy to restore HEXA activity and slow disease progression
Related Products
Mouse β-Hex A (β-hexosaminidase A) ELISA Kit
Ver Producto
Mouse Beta-Hexosaminidase Subunit Alpha (HEXA) ELISA Kit
Mouse Beta-Hexosaminidase Subunit Alpha (HEXA) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse beta hexosaminidase A concentrations in serum, plasma and other biological fluids.
Ver Producto
Human Beta-Hexosaminidase Subunit Alpha (HEXA) Protein (Active)
Human Hexosaminidase A Protein is a recombinant protein from Human produced in Baculovirus-Insect Cells. A DNA sequence encoding the human HEXA (AAD13932.1) (Met 1-Thr 529) was fused with a polyhistidine tag at the C-terminus.
Ver Producto