EDNR - Endothelin Receptor | Elisa - Clia - Antibody - Protein

Family main features


Background:

Endothelin receptors are a class of G protein-coupled receptors (GPCRs) that respond to endothelin peptides. They play crucial roles in regulating vascular tone, blood pressure, cell proliferation, and tissue homeostasis. Endothelin receptors are activated by endothelin peptides, including endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3). These peptides are produced by endothelial cells and exert paracrine and autocrine effects on nearby cells expressing endothelin receptors.


Structural Features:

Endothelin receptors, like other GPCRs, possess seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus. Upon ligand binding, conformational changes in the receptor initiate intracellular signaling cascades through interaction with heterotrimeric G proteins.


Subtypes and Classification:

Endothelin receptors are classified into two main subtypes, designated as endothelin type A (ETA) and endothelin type B (ETB) receptors:

  • Endothelin Type A (ETA) Receptors: ETA receptors are primarily expressed in vascular smooth muscle cells and mediate vasoconstriction and cell proliferation in response to endothelin-1 (ET-1) binding.
  • Endothelin Type B (ETB) Receptors: ETB receptors are expressed in various tissues, including endothelial cells, vascular smooth muscle cells, and kidney tubular cells. They mediate vasodilation, natriuresis, and clearance of endothelin peptides.


Physiological Functions:

Endothelin receptors mediate various physiological effects in different tissues and organ systems:

  • Vascular Regulation: Endothelin receptors play a crucial role in regulating vascular tone and blood pressure by modulating vascular smooth muscle contraction and relaxation.
  • Renal Function: Endothelin receptors in the kidneys regulate renal hemodynamics, electrolyte balance, and fluid volume through effects on renal blood flow, glomerular filtration rate, and tubular ion transport.
  • Cell Proliferation: Endothelin receptors are involved in cell proliferation, migration, and extracellular matrix remodeling in various tissues, contributing to tissue repair, fibrosis, and pathological conditions such as cancer.
  • Neurological Function: Endothelin receptors in the central nervous system (CNS) and peripheral nervous system (PNS) modulate neuronal activity, neurotransmitter release, and nociception, contributing to pain perception and neurological disorders.


Clinical Implications:

Dysregulation of endothelin receptor signaling is associated with various pathological conditions:

  • Cardiovascular Diseases: Altered endothelin receptor activity may contribute to cardiovascular diseases such as hypertension, atherosclerosis, coronary artery disease, heart failure, and pulmonary hypertension.
  • Renal Disorders: Dysfunction of endothelin receptor signaling is implicated in renal disorders such as chronic kidney disease, diabetic nephropathy, and renal fibrosis.
  • Pulmonary Disorders: Changes in endothelin receptor expression or function may be involved in pulmonary disorders such as pulmonary hypertension, asthma, and chronic obstructive pulmonary disease (COPD).


Therapeutic Potential:

Endothelin receptors represent potential targets for therapeutic intervention in various diseases. Pharmacological modulation of endothelin receptor activity, either through antagonists, agonists, or allosteric modulators, holds promise for the development of novel therapies targeting these receptors.

EDNRA Recommended name:

Endothelin Receptor A (EDNRA)

Aliases for EDNRA

EDNRA,ET-AR,ENDOR,endothelinAreceptor,endothelin-1receptor,Gpcr10,ETA,ET-A,ETAR,ETRA,MFDA,ETA-R,hET-AR,Endothelin 1 Receptor

EDNRB Recommended name:

Endothelin Receptor B (EDNRB )

Aliases for EDNRB

EDNRB,HSCR,HSCR2 ,endothelin B receptor ,ET-BR,ETB,ET-B,ETB1,ETBR,ETRB,WS4A,ABCDS

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con EDNR - Endothelin Receptor

Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.

Esta página contiene 44 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaEDNRAabx355653Chicken Endothelin 1 Receptor (EDNRA) ELISA KitChickenSerum, plasma and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml0.1 ng/ml68996 testsRUO
AbbexaEDNRBabx355917Chicken Endothelin B Receptor (EDNRB) ELISA KitChickenSerum, plasma and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml0.19 ng/ml68996 testsRUO
AbbexaEDNRAabx519023Cow Endothelin 1 Receptor (EDNRA) ELISA KitCowTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsP21450RUO
AbbexaEDNRBabx519029Cow Endothelin B Receptor (EDNRB) ELISA KitCowTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsP28088RUO
AbbexaEDNRAabx519024Dog Endothelin 1 Receptor (EDNRA) ELISA KitDogTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ5KSU9RUO
AbbexaEDNRBabx519030Dog Endothelin B Receptor (EDNRB) ELISA KitDogTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsP56497RUO
AbbexaEDNRAabx195563Human Endothelin 1 Receptor (EDNRA) CLIA KitHumanSerum, plasma and other biological fluids.Sandwich31.2 pg/ml - 2000 pg/ml18.8 pg/ml643.596 testsRUO
AbbexaEDNRAabx252414Human Endothelin 1 Receptor (EDNRA) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml0.1 ng/ml61196 testsP25101RUO
AbbexaEDNRAabx493328Human Endothelin 1 Receptor (EDNRA) CLIA KitHumanTissue homogenates and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml< 0.115 ng/ml84596 testsRUO
AbbexaEDNRAabx151411Human Endothelin 1 Receptor (EDNRA) ELISA KitHumanSerum, plasma, tissue homogenates and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml< 0.12 ng/ml68996 testsP25101RUO
AbbexaEDNRBabx493329Human Endothelin B Receptor (EDNRB) CLIA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml< 0.115 ng/ml84596 testsRUO
AbbexaEDNRBabx195564Human Endothelin B Receptor (EDNRB) CLIA KitHumanSerum, plasma and other biological fluids.Sandwich62.5 pg/ml - 4000 pg/ml37.5 pg/ml643.596 testsRUO
AbbexaEDNRBabx252415Human Endothelin B Receptor (EDNRB) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml0.19 ng/ml61196 testsP24530RUO
AbbexaEDNRBabx151412Human Endothelin B Receptor (EDNRB) ELISA KitHumanSerum, plasma, tissue homogenates and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml< 0.12 ng/ml68996 testsRUO
AbbexaEDNRAabx352688Mouse Endothelin 1 Receptor (EDNRA) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml0.19 ng/ml61196 testsQ61614RUO
AbbexaEDNRBabx519032Mouse Endothelin B Receptor (EDNRB) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.Sandwich78 pg/ml - 5000 pg/ml55996 testsP48302RUO
AbbexaEDNRAabx360845Pig Endothelin 1 Receptor (EDNRA) ELISA KitPigSerum, plasma and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml0.1 ng/ml71596 testsRUO
AbbexaEDNRBabx519033Pig Endothelin B Receptor (EDNRB) ELISA KitPigSerum, plasma and other biological fluids.Sandwich0.312 ng/ml - 20 ng/ml0.19 ng/ml71596 testsRUO
AbbexaEDNRAabx363770Rabbit Endothelin 1 Receptor (EDNRA) ELISA KitRabbitSerum, plasma and other biological fluids.Sandwich62.5 pg/ml - 4000 pg/ml37.5 pg/ml68996 testsRUO
AbbexaEDNRBabx362978Rabbit Endothelin B Receptor (EDNRB) ELISA KitRabbitSerum, plasma and other biological fluids.Sandwich125 pg/ml - 8000 pg/ml75 pg/ml68996 testsRUO
AbbexaEDNRAabx519028Rat Endothelin 1 Receptor (EDNRA) ELISA KitRatTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.095 ng/ml578.596 testsP26684RUO
AbbexaEDNRBabx570430Rat Endothelin B Receptor (EDNRB) ELISA KitRatTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml578.596 testsP21451RUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
FineTestEDNRBFNab02637anti- EDNRB antibodyhumanpolyclonalRabbitendothelin receptor type BIgGUnconjugatedELISA, WB, IHC, FC100µgP24530RUO
AbbexaEDNRAabx032836Endothelin Receptor Type A (EDNRA) AntibodyHumanPolyclonalRabbitEndothelin Receptor Type A (EDNRA)IgGUnconjugatedELISA, WB, IF/ICC, FCM292.580 µlP25101RUO
AbbexaEDNRAabx455001Endothelin-1 Receptor (EDNRA) AntibodyHumanPolyclonalRabbitEndothelin-1 Receptor (EDNRA)IgGUnconjugatedELISA, WB, IHC26050 µgP25101RUO
AbbexaEDNRAabx421773Endothelin-1 Receptor (EDNRA) AntibodyHumanMonoclonalHumanEndothelin-1 Receptor (EDNRA)IgG1UnconjugatedELISA, FCM31250 µgP25101RUO
AbbexaEDNRAabx211933Endothelin Receptor Type A (EDNRA) AntibodyHumanPolyclonalRabbitEndothelin Receptor Type A (EDNRA)IgGUnconjugatedELISA, WB, IHC26050 µlP25101RUO
AbbexaEDNRAabx119460Endothelin Receptor Type A (EDNRA) AntibodyHumanPolyclonalRabbitEndothelin Receptor Type A (EDNRA)IgGUnconjugatedWB, IF/ICC5210 µgP25101RUO
AbbexaEDNRAabx326330Endothelin Receptor Type A (EDNRA) AntibodyHumanPolyclonalRabbitEndothelin Receptor Type A (EDNRA)IgGUnconjugatedELISA, WB, IHC, IF/ICC22150 µgP25101RUO
AbbexaEDNRAabx328098Endothelin Receptor Type A (EDNRA) AntibodyHumanPolyclonalRabbitEndothelin Receptor Type A (EDNRA)IgGUnconjugatedELISA, WB, IF/ICC22150 µgP25101RUO
AbbexaEDNRBabx315691Endothelin Receptor Type B (EDNRB) Antibody (Biotin)HumanPolyclonalRabbitEndothelin Receptor Type B (EDNRB)IgGBiotinELISA16920 µgP24530RUO
AbbexaEDNRBabx315690Endothelin Receptor Type B (EDNRB) Antibody (FITC)HumanPolyclonalRabbitEndothelin Receptor Type B (EDNRB)IgGFITC16920 µgP24530RUO
AbbexaEDNRBabx324988Endothelin Receptor Type B (EDNRB) AntibodyHumanPolyclonalRabbitEndothelin Receptor Type B (EDNRB)IgGUnconjugatedELISA, WB22150 µgP24530RUO
AbbexaEDNRBabx421765Endothelin Receptor Type B (EDNRB) AntibodyHumanMonoclonalMouseEndothelin Receptor Type B (EDNRB)IgG2aUnconjugatedELISA, FCM31250 µgP24530RUO
AbbexaEDNRBabx315689Endothelin Receptor Type B (EDNRB) Antibody (HRP)HumanPolyclonalRabbitEndothelin Receptor Type B (EDNRB)IgGHRPELISA16920 µgP24530RUO
AbbexaEDNRBabx377989Endothelin Receptor Type B (EDNRB) AntibodyHumanPolyclonalRabbitEndothelin Receptor Type B (EDNRB)IgGUnconjugatedELISA, WB, IHC26050 µgP24530RUO
AbbexaEDNRBabx339420Endothelin Receptor Type B (EDNRB) AntibodyHumanPolyclonalRabbitEndothelin Receptor Type B (EDNRB)IgGUnconjugatedELISA, IHC26050 µlP24530RUO
AbbexaEDNRBabx211162Endothelin Receptor Type B (EDNRB) AntibodyHumanPolyclonalRabbitEndothelin Receptor Type B (EDNRB)IgGUnconjugatedELISA, WB, IHC26050 µlP24530RUO
AbbexaEDNRBabx232637Endothelin Receptor Type B (EDNRB) AntibodyHumanPolyclonalRabbitEndothelin Receptor Type B (EDNRB)IgGUnconjugatedELISA, WB, IHC, FCM364100 µgP24530RUO
AbbexaEDNRBabx002134Endothelin Receptor Type B (EDNRB) AntibodyHumanPolyclonalRabbitEndothelin Receptor Type B (EDNRB)IgGUnconjugatedELISA, WB19520 µlP24530RUO
AbbexaEDNRBabx318239Endothelin Receptor Type B (EDNRB) AntibodyHumanPolyclonalRabbitEndothelin Receptor Type B (EDNRB)IgGUnconjugatedELISA, WB, IHC, IF/ICC16920 µgP24530RUO
AbbexaEDNRBabx032985Endothelin Receptor Type B (EDNRB) AntibodyHumanPolyclonalRabbitEndothelin Receptor Type B (EDNRB)IgGUnconjugatedELISA, WB, IHC, IF/ICC, FCM292.580 µlP24530RUO
AbbexaEDNRBabx326851Endothelin Receptor Type B (EDNRB) AntibodyHumanPolyclonalRabbitEndothelin Receptor Type B (EDNRB)IgGUnconjugatedELISA, IHC22150 µgP24530RUO
AbbexaEDNRBabx411769Endothelin B Receptor (EDNRB) AntibodyRatPolyclonalSheepEndothelin B Receptor (EDNRB)IgGUnconjugatedIHC, IF/ICC, IP377100 µgP21451, P24530, P48302RUO

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