EDNR - Endothelin Receptor | Elisa - Clia - Antibody - Protein
Family main features
Background:
Endothelin receptors are a class of G protein-coupled receptors (GPCRs) that respond to endothelin peptides. They play crucial roles in regulating vascular tone, blood pressure, cell proliferation, and tissue homeostasis. Endothelin receptors are activated by endothelin peptides, including endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3). These peptides are produced by endothelial cells and exert paracrine and autocrine effects on nearby cells expressing endothelin receptors.
Structural Features:
Endothelin receptors, like other GPCRs, possess seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus. Upon ligand binding, conformational changes in the receptor initiate intracellular signaling cascades through interaction with heterotrimeric G proteins.
Subtypes and Classification:
Endothelin receptors are classified into two main subtypes, designated as endothelin type A (ETA) and endothelin type B (ETB) receptors:
- Endothelin Type A (ETA) Receptors: ETA receptors are primarily expressed in vascular smooth muscle cells and mediate vasoconstriction and cell proliferation in response to endothelin-1 (ET-1) binding.
- Endothelin Type B (ETB) Receptors: ETB receptors are expressed in various tissues, including endothelial cells, vascular smooth muscle cells, and kidney tubular cells. They mediate vasodilation, natriuresis, and clearance of endothelin peptides.
Physiological Functions:
Endothelin receptors mediate various physiological effects in different tissues and organ systems:
- Vascular Regulation: Endothelin receptors play a crucial role in regulating vascular tone and blood pressure by modulating vascular smooth muscle contraction and relaxation.
- Renal Function: Endothelin receptors in the kidneys regulate renal hemodynamics, electrolyte balance, and fluid volume through effects on renal blood flow, glomerular filtration rate, and tubular ion transport.
- Cell Proliferation: Endothelin receptors are involved in cell proliferation, migration, and extracellular matrix remodeling in various tissues, contributing to tissue repair, fibrosis, and pathological conditions such as cancer.
- Neurological Function: Endothelin receptors in the central nervous system (CNS) and peripheral nervous system (PNS) modulate neuronal activity, neurotransmitter release, and nociception, contributing to pain perception and neurological disorders.
Clinical Implications:
Dysregulation of endothelin receptor signaling is associated with various pathological conditions:
- Cardiovascular Diseases: Altered endothelin receptor activity may contribute to cardiovascular diseases such as hypertension, atherosclerosis, coronary artery disease, heart failure, and pulmonary hypertension.
- Renal Disorders: Dysfunction of endothelin receptor signaling is implicated in renal disorders such as chronic kidney disease, diabetic nephropathy, and renal fibrosis.
- Pulmonary Disorders: Changes in endothelin receptor expression or function may be involved in pulmonary disorders such as pulmonary hypertension, asthma, and chronic obstructive pulmonary disease (COPD).
Therapeutic Potential:
Endothelin receptors represent potential targets for therapeutic intervention in various diseases. Pharmacological modulation of endothelin receptor activity, either through antagonists, agonists, or allosteric modulators, holds promise for the development of novel therapies targeting these receptors.
EDNRA Recommended name:
Endothelin Receptor A (EDNRA)
Aliases for EDNRA
EDNRA,ET-AR,ENDOR,endothelinAreceptor,endothelin-1receptor,Gpcr10,ETA,ET-A,ETAR,ETRA,MFDA,ETA-R,hET-AR,Endothelin 1 Receptor
EDNRB Recommended name:
Endothelin Receptor B (EDNRB )
Aliases for EDNRB
EDNRB,HSCR,HSCR2 ,endothelin B receptor ,ET-BR,ETB,ET-B,ETB1,ETBR,ETRB,WS4A,ABCDS
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con EDNR - Endothelin Receptor
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 44 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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immunoassays
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | EDNRA | abx355653 | Chicken Endothelin 1 Receptor (EDNRA) ELISA Kit | Chicken | Serum, plasma and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 689 | 96 tests | RUO | |
Abbexa | EDNRB | abx355917 | Chicken Endothelin B Receptor (EDNRB) ELISA Kit | Chicken | Serum, plasma and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 689 | 96 tests | RUO | |
Abbexa | EDNRA | abx519023 | Cow Endothelin 1 Receptor (EDNRA) ELISA Kit | Cow | Tissue homogenates, cell lysates and other biological fluids. | 0.156 ng/ml - 10 ng/ml | 715 | 96 tests | P21450 | RUO | ||
Abbexa | EDNRB | abx519029 | Cow Endothelin B Receptor (EDNRB) ELISA Kit | Cow | Tissue homogenates, cell lysates and other biological fluids. | 0.156 ng/ml - 10 ng/ml | 715 | 96 tests | P28088 | RUO | ||
Abbexa | EDNRA | abx519024 | Dog Endothelin 1 Receptor (EDNRA) ELISA Kit | Dog | Tissue homogenates, cell lysates and other biological fluids. | 0.156 ng/ml - 10 ng/ml | 715 | 96 tests | Q5KSU9 | RUO | ||
Abbexa | EDNRB | abx519030 | Dog Endothelin B Receptor (EDNRB) ELISA Kit | Dog | Tissue homogenates, cell lysates and other biological fluids. | 0.156 ng/ml - 10 ng/ml | 715 | 96 tests | P56497 | RUO | ||
Abbexa | EDNRA | abx195563 | Human Endothelin 1 Receptor (EDNRA) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 643.5 | 96 tests | RUO | |
Abbexa | EDNRA | abx252414 | Human Endothelin 1 Receptor (EDNRA) ELISA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 611 | 96 tests | P25101 | RUO |
Abbexa | EDNRA | abx493328 | Human Endothelin 1 Receptor (EDNRA) CLIA Kit | Human | Tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.115 ng/ml | 845 | 96 tests | RUO | |
Abbexa | EDNRA | abx151411 | Human Endothelin 1 Receptor (EDNRA) ELISA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 689 | 96 tests | P25101 | RUO |
Abbexa | EDNRB | abx493329 | Human Endothelin B Receptor (EDNRB) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.115 ng/ml | 845 | 96 tests | RUO | |
Abbexa | EDNRB | abx195564 | Human Endothelin B Receptor (EDNRB) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 62.5 pg/ml - 4000 pg/ml | 37.5 pg/ml | 643.5 | 96 tests | RUO | |
Abbexa | EDNRB | abx252415 | Human Endothelin B Receptor (EDNRB) ELISA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 611 | 96 tests | P24530 | RUO |
Abbexa | EDNRB | abx151412 | Human Endothelin B Receptor (EDNRB) ELISA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 689 | 96 tests | RUO | |
Abbexa | EDNRA | abx352688 | Mouse Endothelin 1 Receptor (EDNRA) ELISA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 611 | 96 tests | Q61614 | RUO |
Abbexa | EDNRB | abx519032 | Mouse Endothelin B Receptor (EDNRB) ELISA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 78 pg/ml - 5000 pg/ml | 559 | 96 tests | P48302 | RUO | |
Abbexa | EDNRA | abx360845 | Pig Endothelin 1 Receptor (EDNRA) ELISA Kit | Pig | Serum, plasma and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 715 | 96 tests | RUO | |
Abbexa | EDNRB | abx519033 | Pig Endothelin B Receptor (EDNRB) ELISA Kit | Pig | Serum, plasma and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 715 | 96 tests | RUO | |
Abbexa | EDNRA | abx363770 | Rabbit Endothelin 1 Receptor (EDNRA) ELISA Kit | Rabbit | Serum, plasma and other biological fluids. | Sandwich | 62.5 pg/ml - 4000 pg/ml | 37.5 pg/ml | 689 | 96 tests | RUO | |
Abbexa | EDNRB | abx362978 | Rabbit Endothelin B Receptor (EDNRB) ELISA Kit | Rabbit | Serum, plasma and other biological fluids. | Sandwich | 125 pg/ml - 8000 pg/ml | 75 pg/ml | 689 | 96 tests | RUO | |
Abbexa | EDNRA | abx519028 | Rat Endothelin 1 Receptor (EDNRA) ELISA Kit | Rat | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.095 ng/ml | 578.5 | 96 tests | P26684 | RUO |
Abbexa | EDNRB | abx570430 | Rat Endothelin B Receptor (EDNRB) ELISA Kit | Rat | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | 578.5 | 96 tests | P21451 | RUO |
Primary Antibodies
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | EDNRB | FNab02637 | anti- EDNRB antibody | human | polyclonal | Rabbit | endothelin receptor type B | IgG | Unconjugated | ELISA, WB, IHC, FC | 100µg | P24530 | RUO | |
Abbexa | EDNRA | abx032836 | Endothelin Receptor Type A (EDNRA) Antibody | Human | Polyclonal | Rabbit | Endothelin Receptor Type A (EDNRA) | IgG | Unconjugated | ELISA, WB, IF/ICC, FCM | 292.5 | 80 µl | P25101 | RUO |
Abbexa | EDNRA | abx455001 | Endothelin-1 Receptor (EDNRA) Antibody | Human | Polyclonal | Rabbit | Endothelin-1 Receptor (EDNRA) | IgG | Unconjugated | ELISA, WB, IHC | 260 | 50 µg | P25101 | RUO |
Abbexa | EDNRA | abx421773 | Endothelin-1 Receptor (EDNRA) Antibody | Human | Monoclonal | Human | Endothelin-1 Receptor (EDNRA) | IgG1 | Unconjugated | ELISA, FCM | 312 | 50 µg | P25101 | RUO |
Abbexa | EDNRA | abx211933 | Endothelin Receptor Type A (EDNRA) Antibody | Human | Polyclonal | Rabbit | Endothelin Receptor Type A (EDNRA) | IgG | Unconjugated | ELISA, WB, IHC | 260 | 50 µl | P25101 | RUO |
Abbexa | EDNRA | abx119460 | Endothelin Receptor Type A (EDNRA) Antibody | Human | Polyclonal | Rabbit | Endothelin Receptor Type A (EDNRA) | IgG | Unconjugated | WB, IF/ICC | 52 | 10 µg | P25101 | RUO |
Abbexa | EDNRA | abx326330 | Endothelin Receptor Type A (EDNRA) Antibody | Human | Polyclonal | Rabbit | Endothelin Receptor Type A (EDNRA) | IgG | Unconjugated | ELISA, WB, IHC, IF/ICC | 221 | 50 µg | P25101 | RUO |
Abbexa | EDNRA | abx328098 | Endothelin Receptor Type A (EDNRA) Antibody | Human | Polyclonal | Rabbit | Endothelin Receptor Type A (EDNRA) | IgG | Unconjugated | ELISA, WB, IF/ICC | 221 | 50 µg | P25101 | RUO |
Abbexa | EDNRB | abx315691 | Endothelin Receptor Type B (EDNRB) Antibody (Biotin) | Human | Polyclonal | Rabbit | Endothelin Receptor Type B (EDNRB) | IgG | Biotin | ELISA | 169 | 20 µg | P24530 | RUO |
Abbexa | EDNRB | abx315690 | Endothelin Receptor Type B (EDNRB) Antibody (FITC) | Human | Polyclonal | Rabbit | Endothelin Receptor Type B (EDNRB) | IgG | FITC | 169 | 20 µg | P24530 | RUO | |
Abbexa | EDNRB | abx324988 | Endothelin Receptor Type B (EDNRB) Antibody | Human | Polyclonal | Rabbit | Endothelin Receptor Type B (EDNRB) | IgG | Unconjugated | ELISA, WB | 221 | 50 µg | P24530 | RUO |
Abbexa | EDNRB | abx421765 | Endothelin Receptor Type B (EDNRB) Antibody | Human | Monoclonal | Mouse | Endothelin Receptor Type B (EDNRB) | IgG2a | Unconjugated | ELISA, FCM | 312 | 50 µg | P24530 | RUO |
Abbexa | EDNRB | abx315689 | Endothelin Receptor Type B (EDNRB) Antibody (HRP) | Human | Polyclonal | Rabbit | Endothelin Receptor Type B (EDNRB) | IgG | HRP | ELISA | 169 | 20 µg | P24530 | RUO |
Abbexa | EDNRB | abx377989 | Endothelin Receptor Type B (EDNRB) Antibody | Human | Polyclonal | Rabbit | Endothelin Receptor Type B (EDNRB) | IgG | Unconjugated | ELISA, WB, IHC | 260 | 50 µg | P24530 | RUO |
Abbexa | EDNRB | abx339420 | Endothelin Receptor Type B (EDNRB) Antibody | Human | Polyclonal | Rabbit | Endothelin Receptor Type B (EDNRB) | IgG | Unconjugated | ELISA, IHC | 260 | 50 µl | P24530 | RUO |
Abbexa | EDNRB | abx211162 | Endothelin Receptor Type B (EDNRB) Antibody | Human | Polyclonal | Rabbit | Endothelin Receptor Type B (EDNRB) | IgG | Unconjugated | ELISA, WB, IHC | 260 | 50 µl | P24530 | RUO |
Abbexa | EDNRB | abx232637 | Endothelin Receptor Type B (EDNRB) Antibody | Human | Polyclonal | Rabbit | Endothelin Receptor Type B (EDNRB) | IgG | Unconjugated | ELISA, WB, IHC, FCM | 364 | 100 µg | P24530 | RUO |
Abbexa | EDNRB | abx002134 | Endothelin Receptor Type B (EDNRB) Antibody | Human | Polyclonal | Rabbit | Endothelin Receptor Type B (EDNRB) | IgG | Unconjugated | ELISA, WB | 195 | 20 µl | P24530 | RUO |
Abbexa | EDNRB | abx318239 | Endothelin Receptor Type B (EDNRB) Antibody | Human | Polyclonal | Rabbit | Endothelin Receptor Type B (EDNRB) | IgG | Unconjugated | ELISA, WB, IHC, IF/ICC | 169 | 20 µg | P24530 | RUO |
Abbexa | EDNRB | abx032985 | Endothelin Receptor Type B (EDNRB) Antibody | Human | Polyclonal | Rabbit | Endothelin Receptor Type B (EDNRB) | IgG | Unconjugated | ELISA, WB, IHC, IF/ICC, FCM | 292.5 | 80 µl | P24530 | RUO |
Abbexa | EDNRB | abx326851 | Endothelin Receptor Type B (EDNRB) Antibody | Human | Polyclonal | Rabbit | Endothelin Receptor Type B (EDNRB) | IgG | Unconjugated | ELISA, IHC | 221 | 50 µg | P24530 | RUO |
Abbexa | EDNRB | abx411769 | Endothelin B Receptor (EDNRB) Antibody | Rat | Polyclonal | Sheep | Endothelin B Receptor (EDNRB) | IgG | Unconjugated | IHC, IF/ICC, IP | 377 | 100 µg | P21451, P24530, P48302 | RUO |
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