Endothelin Receptor Type B (EDNRB) Antibody
260€ (50 µl)
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Name
Endothelin Receptor Type B (EDNRB) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx211162
Tested Applications
ELISA, WB, IHC
Description
EDNRB Antibody is a Rabbit Polyclonal against EDNRB.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Endothelin Receptor Type B (EDNRB) Immunogen: Synthetic peptide of human EDNRB. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, WB: 1/500 - 1/2000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P24530 |
| Gene ID | 1910 |
| Alias | EDNRB,HSCR,HSCR2 ,endothelin B receptor ,ET-BR,ETB,ET-B,ETB1,ETBR,ETRB,WS4A,ABCDS |
| Background | Antibody anti-EDNRB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
EDNRB is a G protein-coupled receptor that binds endothelin-1 (ET-1), endothelin-2, and endothelin-3 with equal affinity, playing key roles in vasodilation, endothelial function, and neural crest cell development. EDNRB is primarily expressed on endothelial cells, where its activation stimulates the release of nitric oxide (NO) and prostacyclin, leading to vasodilation and reduced vascular tone. It also mediates endothelin clearance, regulating ET-1 levels in circulation. During development, EDNRB is essential for neural crest cell migration and differentiation, with mutations in EDNRB linked to Hirschsprung’s disease and Waardenburg syndrome. In cardiovascular physiology, EDNRB balances the vasoconstrictive effects of EDNRA by promoting vasodilation and endothelial repair, but its dysregulation can contribute to pulmonary arterial hypertension (PAH) and vascular dysfunction. In cancer, EDNRB expression on tumor cells and stromal cells has been linked to enhanced tumor invasion, metastasis, and angiogenesis, particularly in melanoma and colorectal cancers. EDNRB signaling also modulates immune responses and inflammation in pathological conditions. Therapeutically, selective modulation of EDNRB is being explored to restore vascular function and manage diseases like PAH and specific cancers. EDNRB thus serves as a key regulator of vascular homeostasis, development, and disease progression.
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