Endothelin Receptor Type B (EDNRB) Antibody
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Description
EDNRB is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Endothelin Receptor Type B (EDNRB) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P24530 |
| NCBI Accession | NP_000106.1, NP_001116131.1, NP_001188326.1, NP_003982.1 |
| Alias | EDNRB,HSCR,HSCR2 ,endothelin B receptor ,ET-BR,ETB,ET-B,ETB1,ETBR,ETRB,WS4A,ABCDS |
| Background | Antibody anti-EDNRB |
| Status | RUO |
Descripción
EDNRB is a G protein-coupled receptor that binds endothelin-1 (ET-1), endothelin-2, and endothelin-3 with equal affinity, playing key roles in vasodilation, endothelial function, and neural crest cell development. EDNRB is primarily expressed on endothelial cells, where its activation stimulates the release of nitric oxide (NO) and prostacyclin, leading to vasodilation and reduced vascular tone. It also mediates endothelin clearance, regulating ET-1 levels in circulation. During development, EDNRB is essential for neural crest cell migration and differentiation, with mutations in EDNRB linked to Hirschsprung’s disease and Waardenburg syndrome. In cardiovascular physiology, EDNRB balances the vasoconstrictive effects of EDNRA by promoting vasodilation and endothelial repair, but its dysregulation can contribute to pulmonary arterial hypertension (PAH) and vascular dysfunction. In cancer, EDNRB expression on tumor cells and stromal cells has been linked to enhanced tumor invasion, metastasis, and angiogenesis, particularly in melanoma and colorectal cancers. EDNRB signaling also modulates immune responses and inflammation in pathological conditions. Therapeutically, selective modulation of EDNRB is being explored to restore vascular function and manage diseases like PAH and specific cancers. EDNRB thus serves as a key regulator of vascular homeostasis, development, and disease progression.
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EDNRB antibody
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
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Endothelin Receptor Type B (EDNRB) Antibody
EDNRB Antibody is a Rabbit Polyclonal antibody against EDNRB. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Endothelin Receptor Type B (EDNRB) Antibody
EDNRB is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene.
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