Endothelin Receptor Type A (EDNRA) Antibody
260€ (50 µl)
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Name
Endothelin Receptor Type A (EDNRA) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx211933
Tested Applications
ELISA, WB, IHC
Description
EDNRA Antibody is a Rabbit Polyclonal against EDNRA.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Endothelin Receptor Type A (EDNRA) Immunogen: Synthetic peptide of human EDNRA. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, WB: 1/200 - 1/1000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P25101 |
| Gene ID | 1909 |
| Alias | EDNRA,ET-AR,ENDOR,endothelin A receptor,endothelin-1 receptor,Gpcr10,ETA,ET-A,ETAR,ETRA,MFDA,ETA-R,hET-AR,Endothelin 1 Receptor |
| Background | Antibody anti-EDNRA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
EDNRA is a G protein-coupled receptor (GPCR) that binds endothelin-1 (ET-1) with high affinity, playing a critical role in regulating vascular tone, cell proliferation, and cardiac function. It is predominantly expressed on vascular smooth muscle cells, where its activation by ET-1 triggers potent vasoconstriction through downstream signaling pathways, including phospholipase C (PLC), protein kinase C (PKC), and calcium mobilization. EDNRA-mediated signaling is essential for maintaining blood pressure and vascular homeostasis but contributes to pathological conditions such as hypertension, pulmonary arterial hypertension (PAH), and atherosclerosis when dysregulated. In cancer, EDNRA is overexpressed in tumors, including breast, ovarian, and prostate cancers, where it promotes cell proliferation, survival, angiogenesis, and metastasis by enhancing ET-1 signaling. EDNRA activation also contributes to cardiac hypertrophy and fibrosis in heart failure, making it a therapeutic target for cardiovascular diseases. Pharmacological antagonists of EDNRA, such as endothelin receptor antagonists (ERAs), have shown efficacy in managing PAH and reducing vascular remodeling. Overall, EDNRA plays a vital role in vascular physiology and disease, with its dysregulation driving cardiovascular pathology and tumor progression.
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