Cow Endothelin B Receptor (EDNRB) ELISA Kit

Product specifications

ELISA Kits

Endothelin B Receptor (EDNRB)

Cow

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-12 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

P28088

EDNRB,HSCR,HSCR2 ,endothelin B receptor ,ET-BR,ETB,ET-B,ETB1,ETBR,ETRB,WS4A,ABCDS

Elisa kits for EDNRB

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

EDNRB is a G protein-coupled receptor that binds endothelin-1 (ET-1), endothelin-2, and endothelin-3 with equal affinity, playing key roles in vasodilation, endothelial function, and neural crest cell development. EDNRB is primarily expressed on endothelial cells, where its activation stimulates the release of nitric oxide (NO) and prostacyclin, leading to vasodilation and reduced vascular tone. It also mediates endothelin clearance, regulating ET-1 levels in circulation. During development, EDNRB is essential for neural crest cell migration and differentiation, with mutations in EDNRB linked to Hirschsprung’s disease and Waardenburg syndrome. In cardiovascular physiology, EDNRB balances the vasoconstrictive effects of EDNRA by promoting vasodilation and endothelial repair, but its dysregulation can contribute to pulmonary arterial hypertension (PAH) and vascular dysfunction. In cancer, EDNRB expression on tumor cells and stromal cells has been linked to enhanced tumor invasion, metastasis, and angiogenesis, particularly in melanoma and colorectal cancers. EDNRB signaling also modulates immune responses and inflammation in pathological conditions. Therapeutically, selective modulation of EDNRB is being explored to restore vascular function and manage diseases like PAH and specific cancers. EDNRB thus serves as a key regulator of vascular homeostasis, development, and disease progression.

Related Products

anti- EDNRB antibody

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

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Endothelin Receptor Type B (EDNRB) Antibody

EDNRB Antibody is a Rabbit Polyclonal antibody against EDNRB. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Endothelin Receptor Type B (EDNRB) Antibody

EDNRB is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene.

Ver Producto