Human Endothelin 1 Receptor (EDNRA) ELISA Kit
689€ (96 tests)
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name
Human Endothelin 1 Receptor (EDNRA) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx151411
tested applications
ELISA
Description
Human Endothelin 1 Receptor (EDNRA) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Endothelin 1 Receptor (EDNRA) concentrations in serum, plasma, tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Endothelin Receptor A (ETRA)
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Endothelin 1 Receptor (EDNRA) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.12 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P25101 |
| Alias | EDNRA,ET-AR,ENDOR,endothelin A receptor,endothelin-1 receptor,Gpcr10,ETA,ET-A,ETAR,ETRA,MFDA,ETA-R,hET-AR,Endothelin 1 Receptor |
| Background | Elisa kits for EDNRA |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
EDNRA is a G protein-coupled receptor (GPCR) that binds endothelin-1 (ET-1) with high affinity, playing a critical role in regulating vascular tone, cell proliferation, and cardiac function. It is predominantly expressed on vascular smooth muscle cells, where its activation by ET-1 triggers potent vasoconstriction through downstream signaling pathways, including phospholipase C (PLC), protein kinase C (PKC), and calcium mobilization. EDNRA-mediated signaling is essential for maintaining blood pressure and vascular homeostasis but contributes to pathological conditions such as hypertension, pulmonary arterial hypertension (PAH), and atherosclerosis when dysregulated. In cancer, EDNRA is overexpressed in tumors, including breast, ovarian, and prostate cancers, where it promotes cell proliferation, survival, angiogenesis, and metastasis by enhancing ET-1 signaling. EDNRA activation also contributes to cardiac hypertrophy and fibrosis in heart failure, making it a therapeutic target for cardiovascular diseases. Pharmacological antagonists of EDNRA, such as endothelin receptor antagonists (ERAs), have shown efficacy in managing PAH and reducing vascular remodeling. Overall, EDNRA plays a vital role in vascular physiology and disease, with its dysregulation driving cardiovascular pathology and tumor progression.
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