Family main features
The Down Syndrome Cell Adhesion Molecule (DSCAM) is a member of the immunoglobulin superfamily of cell adhesion molecules, crucial for nervous system development and function. DSCAM was first identified due to its potential involvement in Down syndrome, a genetic disorder caused by the presence of an extra copy of chromosome 21. The DSCAM gene is located on this chromosome and has been implicated in various neurological and developmental processes. The importance of DSCAM extends beyond its association with Down syndrome; it plays a significant role in axon guidance, synaptic formation, and neural circuit assembly.
DSCAM is a complex protein with a modular architecture typical of cell adhesion molecules. It consists of several distinct domains:
The structure of DSCAM allows it to participate in diverse cellular processes by mediating interactions with other proteins and signaling pathways. The ability of DSCAM to form homophilic interactions, where it binds to another DSCAM molecule on an adjacent cell, is essential for its role in cell adhesion and neural network formation.
DSCAM belongs to the immunoglobulin superfamily (IgSF), a large group of proteins involved in recognition, binding, or adhesion processes in cells. Within this family, DSCAM is further classified as a cell adhesion molecule.
In Drosophila melanogaster (fruit flies), DSCAM exhibits extraordinary molecular diversity through alternative splicing, resulting in thousands of isoforms. This diversity is crucial for the precise wiring of neural circuits. In humans and other vertebrates, while DSCAM also undergoes alternative splicing, the extent of isoform diversity is less pronounced but still significant for its functional versatility.
DSCAM is vital for several developmental and physiological processes:
Alterations in DSCAM expression or function have been associated with several clinical conditions:
DSCAM is a critical cell adhesion molecule involved in neural development, synapse formation, neuronal migration, and immune function. Its structure, consisting of multiple Ig and FNIII domains, facilitates its role in cell-cell interactions and signal transduction. DSCAM's functions are vital for the proper formation and maintenance of neural circuits, and its dysregulation is associated with various clinical conditions, including Down syndrome, neurodevelopmental disorders, congenital heart defects, and cancer. Understanding the molecular mechanisms of DSCAM and its interactions remains essential for developing therapeutic strategies for these conditions.
DS cell adhesion molecule (DSCAM)
CHD2,CHD2-42,CHD2-52,Down syndrome cell adhesion molecule
DS cell adhesion molecule like 1 (DSCAML1)
DSCAM2,Down syndrome cell adhesion molecule-like protein 1,Down syndrome cell adhesion molecule 2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con DSCAM - DS cell adhesion molecule
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 11 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | DSCAM | abx384809 | Human Down Syndrome Cell Adhesion Molecule (DSCAM) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | O60469 | RUO |
Abbexa | DSCAML1 | abx384810 | Human Downs Syndrome Cell Adhesion Molecule Like 1 (DSCAML1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.188 ng/ml | 687.5 | 96 tests | Q8TD84 | RUO |
Abbexa | DSCAM | abx389101 | Mouse Down Syndrome Cell Adhesion Molecule (DSCAM) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 687.5 | 96 tests | Q9ERC8 | RUO |
Abbexa | DSCAML1 | abx389102 | Mouse Downs Syndrome Cell Adhesion Molecule Like 1 (DSCAML1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q4VA61 | RUO |
Abbexa | DSCAM | abx391247 | Rat Down Syndrome Cell Adhesion Molecule (DSCAM) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 687.5 | 96 tests | Q8VHZ8 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | DSCAM | abx431217 | Down Syndrome Cell Adhesion Molecule Homolog (DSCAM) Antibody | Human | Polyclonal | Goat | Down Syndrome Cell Adhesion Molecule Homolog (DSCAM) | Unconjugated | P-ELISA, WB, IF/ICC, FCM | 387.5 | 200 µl | RUO | ||
Abbexa | DSCAM | abx334273 | Down syndrome cell adhesion molecule homolog (DSCAM) Antibody | Human | Polyclonal | Rabbit | Down syndrome cell adhesion molecule homolog (DSCAM) | Unconjugated | ELISA, IHC | 162.5 | 20 µg | O60469 | RUO | |
Abbexa | DSCAM | abx335458 | Down syndrome cell adhesion molecule homolog (DSCAM) Antibody (FITC) | Human | Polyclonal | Rabbit | Down syndrome cell adhesion molecule homolog (DSCAM) | FITC | 162.5 | 20 µg | O60469 | RUO | ||
Abbexa | DSCAM | abx335459 | Down syndrome cell adhesion molecule homolog (DSCAM) Antibody (Biotin) | Human | Polyclonal | Rabbit | Down syndrome cell adhesion molecule homolog (DSCAM) | Biotin | ELISA | 162.5 | 20 µg | O60469 | RUO | |
Abbexa | DSCAM | abx335457 | Down syndrome cell adhesion molecule homolog (DSCAM) Antibody (HRP) | Human | Polyclonal | Rabbit | Down syndrome cell adhesion molecule homolog (DSCAM) | HRP | ELISA | 162.5 | 20 µg | O60469 | RUO | |
Abbexa | DSCAM | abx375989 | Down Syndrome Cell Adhesion Molecule Homolog (DSCAM) Antibody | Human | Polyclonal | Rabbit | Down Syndrome Cell Adhesion Molecule Homolog (DSCAM) | Unconjugated | ELISA, WB | 337.5 | 100 µg | O60469 | RUO |
Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.