935106861
info@markelab.com
Precio
687.5€ (96 tests)
Rat Down Syndrome Cell Adhesion Molecule (DSCAM) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Down Syndrome Cell Adhesion Molecule (DSCAM) concentrations in tissue homogenates, cell lysates and other biological fluids.
DSCAM (Down Syndrome Cell Adhesion Molecule) is a highly versatile transmembrane protein belonging to the immunoglobulin superfamily, involved in neuronal development, cell adhesion, and immune function. DSCAM is known for its extraordinary molecular diversity, generated through alternative splicing, resulting in thousands of isoforms that mediate highly specific cell-cell interactions. In the nervous system, DSCAM plays critical roles in axon guidance, synapse formation, and dendritic self-avoidance, where individual neurons recognize and avoid their own dendrites to establish proper connectivity. In addition, DSCAM is implicated in non-neuronal processes such as immune responses, where it facilitates phagocytosis in certain immune cells. Dysregulation or overexpression of DSCAM has been linked to neurodevelopmental disorders, including Down syndrome, where its gene is overexpressed due to trisomy 21, contributing to cognitive deficits and abnormal brain development. Structurally, DSCAM consists of immunoglobulin and fibronectin domains that mediate its adhesive and signaling functions, with expression patterns that vary across tissues and developmental stages.
ELISA Kits
Down Syndrome Cell Adhesion Molecule (DSCAM)
Rat
78 pg/ml - 5000 pg/ml
< 46.9 pg/ml
Sandwich
Quantitative
Colorimetric
Tissue homogenates,Cell lysates,Other biological fluids
96 tests
CHD2,CHD2-42,CHD2-52,Down syndrome cell adhesion molecule
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
DSCAM
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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