Down Syndrome Cell Adhesion Molecule Homolog (DSCAM) Antibody
351€ (100 µg)
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935106861
info@markelab.com
name
Down Syndrome Cell Adhesion Molecule Homolog (DSCAM) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx375989
tested applications
ELISA, WB
Description
Down Syndrome Cell Adhesion Molecule Homolog (DSCAM) Antibody is a Rabbit Polyclonal antibody against Down Syndrome Cell Adhesion Molecule Homolog (DSCAM).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Down Syndrome Cell Adhesion Molecule Homolog (DSCAM) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60469 |
| Gene ID | 1826 |
| Alias | CHD2,CHD2-42,CHD2-52,Down syndrome cell adhesion molecule |
| Background | Antibody anti-DSCAM |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
DSCAM (Down Syndrome Cell Adhesion Molecule) is a highly versatile transmembrane protein belonging to the immunoglobulin superfamily, involved in neuronal development, cell adhesion, and immune function. DSCAM is known for its extraordinary molecular diversity, generated through alternative splicing, resulting in thousands of isoforms that mediate highly specific cell-cell interactions. In the nervous system, DSCAM plays critical roles in axon guidance, synapse formation, and dendritic self-avoidance, where individual neurons recognize and avoid their own dendrites to establish proper connectivity. In addition, DSCAM is implicated in non-neuronal processes such as immune responses, where it facilitates phagocytosis in certain immune cells. Dysregulation or overexpression of DSCAM has been linked to neurodevelopmental disorders, including Down syndrome, where its gene is overexpressed due to trisomy 21, contributing to cognitive deficits and abnormal brain development. Structurally, DSCAM consists of immunoglobulin and fibronectin domains that mediate its adhesive and signaling functions, with expression patterns that vary across tissues and developmental stages.
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