Down syndrome cell adhesion molecule homolog (DSCAM) Antibody (HRP)

Este producto es parte de DSCAM - DS cell adhesion molecule
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169€ (20 µg)

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935106861
info@markelab.com
name
Down syndrome cell adhesion molecule homolog (DSCAM) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx335457
tested applications
ELISA

Description

DSCAM Antibody (HRP) is a Rabbit Polyclonal against DSCAM.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Down syndrome cell adhesion molecule homolog (DSCAM)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
HRP
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O60469
Gene ID
1826
Alias
CHD2,CHD2-42,CHD2-52,Down syndrome cell adhesion molecule
Background
Antibody anti-DSCAM
Status
RUO

Descripción

DSCAM (Down Syndrome Cell Adhesion Molecule) is a highly versatile transmembrane protein belonging to the immunoglobulin superfamily, involved in neuronal development, cell adhesion, and immune function. DSCAM is known for its extraordinary molecular diversity, generated through alternative splicing, resulting in thousands of isoforms that mediate highly specific cell-cell interactions. In the nervous system, DSCAM plays critical roles in axon guidance, synapse formation, and dendritic self-avoidance, where individual neurons recognize and avoid their own dendrites to establish proper connectivity. In addition, DSCAM is implicated in non-neuronal processes such as immune responses, where it facilitates phagocytosis in certain immune cells. Dysregulation or overexpression of DSCAM has been linked to neurodevelopmental disorders, including Down syndrome, where its gene is overexpressed due to trisomy 21, contributing to cognitive deficits and abnormal brain development. Structurally, DSCAM consists of immunoglobulin and fibronectin domains that mediate its adhesive and signaling functions, with expression patterns that vary across tissues and developmental stages.

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