Down syndrome cell adhesion molecule homolog (DSCAM) Antibody (HRP)

Este producto es parte de DSCAM - DS cell adhesion molecule
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169€ (20 µg)

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935106861
info@markelab.com
name
Down syndrome cell adhesion molecule homolog (DSCAM) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx335457
tested applications
ELISA

Description

DSCAM Antibody (HRP) is a Rabbit Polyclonal against DSCAM.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetDown syndrome cell adhesion molecule homolog (DSCAM)
HostRabbit
ReactivityHuman
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationHRP
IsotypeIgG
Purity> 95%
PurificationPurified by Protein G.
Size 120 µg
Size 250 µg
Size 3100 µg
Size 4200 µg
Size 51 mg
FormLiquid
Tested ApplicationsELISA
Buffer0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDO60469
Gene ID1826
AliasCHD2,CHD2-42,CHD2-52,Down syndrome cell adhesion molecule
BackgroundAntibody anti-DSCAM
StatusRUO

Descripción

DSCAM (Down Syndrome Cell Adhesion Molecule) is a highly versatile transmembrane protein belonging to the immunoglobulin superfamily, involved in neuronal development, cell adhesion, and immune function. DSCAM is known for its extraordinary molecular diversity, generated through alternative splicing, resulting in thousands of isoforms that mediate highly specific cell-cell interactions. In the nervous system, DSCAM plays critical roles in axon guidance, synapse formation, and dendritic self-avoidance, where individual neurons recognize and avoid their own dendrites to establish proper connectivity. In addition, DSCAM is implicated in non-neuronal processes such as immune responses, where it facilitates phagocytosis in certain immune cells. Dysregulation or overexpression of DSCAM has been linked to neurodevelopmental disorders, including Down syndrome, where its gene is overexpressed due to trisomy 21, contributing to cognitive deficits and abnormal brain development. Structurally, DSCAM consists of immunoglobulin and fibronectin domains that mediate its adhesive and signaling functions, with expression patterns that vary across tissues and developmental stages.

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