Down syndrome cell adhesion molecule homolog (DSCAM) Antibody (Biotin)
169€ (20 µg)
169€ (20 µg)
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name
Down syndrome cell adhesion molecule homolog (DSCAM) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx335459
tested applications
ELISA
Descripción del producto
DSCAM Antibody (Biotin) is a Rabbit Polyclonal against DSCAM.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | CHD2,CHD2-42,CHD2-52,Down syndrome cell adhesion molecule |
| Availability | Shipped within 5-10 working days. |
| Background | Antibody anti-DSCAM |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Dry Ice | No |
| Form | Liquid |
| Gene ID | 1826 |
| Host | Rabbit |
| Immunogen Target | Down syndrome cell adhesion molecule homolog (DSCAM) |
| Isotype | IgG |
| Name | Down syndrome cell adhesion molecule homolog (DSCAM) Antibody (Biotin) |
| Price | 169 |
| Provider | Abbexa |
| Purification | Purified by Protein G. |
| Purity | > 95% |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx335459 |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Tested Applications | ELISA |
| UniProt ID | O60469 |
Descripcion del producto en español
Background en español
DSCAM (Down Syndrome Cell Adhesion Molecule) is a highly versatile transmembrane protein belonging to the immunoglobulin superfamily, involved in neuronal development, cell adhesion, and immune function. DSCAM is known for its extraordinary molecular diversity, generated through alternative splicing, resulting in thousands of isoforms that mediate highly specific cell-cell interactions. In the nervous system, DSCAM plays critical roles in axon guidance, synapse formation, and dendritic self-avoidance, where individual neurons recognize and avoid their own dendrites to establish proper connectivity. In addition, DSCAM is implicated in non-neuronal processes such as immune responses, where it facilitates phagocytosis in certain immune cells. Dysregulation or overexpression of DSCAM has been linked to neurodevelopmental disorders, including Down syndrome, where its gene is overexpressed due to trisomy 21, contributing to cognitive deficits and abnormal brain development. Structurally, DSCAM consists of immunoglobulin and fibronectin domains that mediate its adhesive and signaling functions, with expression patterns that vary across tissues and developmental stages.
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