Family main features
Jagged-1 (JAG1) is a critical ligand within the Notch signaling pathway, a key cell-to-cell communication mechanism that regulates cellular differentiation, proliferation, and apoptosis. This pathway is pivotal during embryonic development and maintains tissue homeostasis in adults. JAG1, specifically, is one of the five canonical Notch ligands (alongside JAG2, DLL1, DLL3, and DLL4) and is highly involved in multiple developmental processes such as neurogenesis, vasculogenesis, and skeletal development. The interaction of JAG1 with Notch receptors triggers a series of proteolytic cleavages and releases the Notch intracellular domain (NICD), which translocates to the nucleus and activates target gene transcription. Dysregulation of JAG1 or aberrations in the Notch pathway are linked to congenital disorders, cancers, and other pathological conditions. In particular, mutations in JAG1 are associated with Alagille syndrome, a multisystem disorder affecting the liver, heart, and other organs.
The structure of JAG1 is complex, with multiple functional domains that facilitate its interaction with Notch receptors and mediate its activity within the cell:
Extracellular Domain:
Transmembrane Domain:
Intracellular Domain:
JAG1 is part of the Notch ligand family, specifically the Jagged subfamily, which includes two members: JAG1 and JAG2. These ligands are distinct from the Delta-like ligands (DLL1, DLL3, and DLL4) in their ability to bind multiple Notch receptors and their unique structural features, such as more extensive EGF-like repeats. No additional isoforms or subtypes of JAG1 have been identified; however, alternative splicing events or post-translational modifications, such as glycosylation, can influence JAG1’s interaction with Notch receptors. This classification helps separate Jagged ligands from Delta-like ligands due to their differential roles in developmental pathways and tissue-specific expression.
Activation of Notch Signaling:
Role in Development:
Cellular Processes:
Alagille Syndrome:
Cancer:
Cardiovascular Diseases:
Inflammatory and Fibrotic Disorders:
Neurological Disorders:
Jagged-1 (JAG1) is a Notch ligand that serves essential functions in cellular differentiation, tissue development, and immune cell function through its activation of the Notch signaling pathway. Structurally, JAG1 is a transmembrane protein composed of a signal peptide, DSL domain, EGF-like repeats, a transmembrane region, and a short intracellular tail. These domains contribute to JAG1’s ability to bind Notch receptors on neighboring cells, facilitating proteolytic activation and nuclear signaling via the Notch intracellular domain (NICD). The activation of Notch signaling by JAG1 is involved in several developmental processes, including neurogenesis, angiogenesis, hematopoiesis, and skeletal development, underscoring its importance in embryonic growth and adult tissue homeostasis.
Clinically, mutations in JAG1 are linked to Alagille syndrome, a multisystem developmental disorder, and dysregulation of JAG1-Notch signaling has been implicated in cancers, cardiovascular diseases, and fibrosis. Overexpression of JAG1 in cancers is associated with poor prognosis, promoting tumor growth, EMT, and metastasis. Efforts to modulate JAG1 signaling, particularly in cancer and fibrotic diseases, are being investigated as potential therapeutic interventions.
jagged canonical Notch ligand 1 (JAG1)
Protein jagged-1,AGS,AHD,AWS,HJ1,AGS1,DCHE,CD339,JAGL1,CMT2HH,Jagged1
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con JAG1 - jagged canonical Notch ligand 1
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 30 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | JAG1 | EH4500 | Human JAG1(Protein jagged-1)elisa kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | P78504 | RUO | ||
Abbexa | JAG1 | abx493101 | Human Jagged 1 Protein (JAG1) CLIA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.056 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | JAG1 | abx152071 | Human Jagged 1 Protein (JAG1) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 618.75 | 96 tests | RUO | |
FineTest | JAG1 | EM1918 | Mouse Jag1 (Protein jagged-1) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | Q9QXX0 | RUO | ||
Abbexa | JAG1 | abx154277 | Mouse Jagged 1 Protein (JAG1) ELISA Kit | Mouse | Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 675 | 96 tests | RUO | |
Abbexa | JAG1 | abx493102 | Mouse Jagged 1 Protein (JAG1) CLIA Kit | Mouse | Tissue homogenates and other biological fluids. | Sandwich | 15.62 pg/ml - 1000 pg/ml | < 6.0 pg/ml | 812.5 | 96 tests | RUO | |
FineTest | JAG1 | ER0639 | Rat Jag1(Protein jagged-1) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 78.125-5000pg/ml | 96T | Q63722 | RUO | ||
Abbexa | JAG1 | abx256614 | Rat Protein jagged-1 (JAG1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 687.5 | 96 tests | Q63722 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | JAG1 | abx315964 | Protein Jagged-1 (JAG1) Antibody (FITC) | Human | Polyclonal | Rabbit | Protein Jagged-1 (JAG1) | FITC | 162.5 | 20 µg | P78504 | RUO | ||
Abbexa | JAG1 | abx302273 | Protein Jagged-1 (JAG1) Antibody | Human | Polyclonal | Rabbit | Protein Jagged-1 (JAG1) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | P78504 | RUO | |
Abbexa | JAG1 | abx315963 | Protein Jagged-1 (JAG1) Antibody (HRP) | Human | Polyclonal | Rabbit | Protein Jagged-1 (JAG1) | HRP | ELISA | 162.5 | 20 µg | P78504 | RUO | |
Abbexa | JAG1 | abx101517 | Jagged 1 Protein (JAG1) Antibody | Human | Polyclonal | Rabbit | Jagged 1 Protein (JAG1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P78504 | RUO | |
Abbexa | JAG1 | abx037271 | Protein Jagged-1 (JAG1) Antibody | Human | Polyclonal | Rabbit | Protein Jagged-1 (JAG1) | Unconjugated | ELISA, IHC | 337.5 | 100 µg | BC126205 | RUO | |
Abbexa | JAG1 | abx101518 | Jagged 1 Protein (JAG1) Antibody | Human | Polyclonal | Rabbit | Jagged 1 Protein (JAG1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P78504 | RUO | |
Abbexa | JAG1 | abx272192 | Jagged 1 Protein (JAG1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Jagged 1 Protein (JAG1) | Biotin | WB, IHC, IF/ICC | 350 | 200 µl | RUO | ||
Abbexa | JAG1 | abx274491 | Jagged 1 Protein (JAG1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Jagged 1 Protein (JAG1) | Biotin | WB, IHC, IF/ICC | 350 | 200 µl | RUO | ||
Abbexa | JAG1 | abx173207 | Jagged 1 Protein (JAG1) Antibody | Human | Monoclonal | Mouse | Jagged 1 Protein (JAG1) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | JAG1 | abx315965 | Protein Jagged-1 (JAG1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Protein Jagged-1 (JAG1) | Biotin | ELISA | 162.5 | 20 µg | P78504 | RUO | |
Abbexa | JAG1 | abx038125 | Protein Jagged-1 (JAG1) Antibody | Human | Polyclonal | Rabbit | Protein Jagged-1 (JAG1) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | JAG1 | abx101519 | Jagged 1 Protein (JAG1) Antibody | Human | Polyclonal | Rabbit | Jagged 1 Protein (JAG1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P78504 | RUO | |
Abbexa | JAG1 | abx431368 | Protein Jagged-1 (JAG1) Antibody | Human | Polyclonal | Goat | Protein Jagged-1 (JAG1) | Unconjugated | P-ELISA, IHC, IF/ICC | 387.5 | 200 µl | RUO | ||
Abbexa | JAG1 | abx213868 | Protein Jagged-1 (JAG1) Antibody | Human | Polyclonal | Rabbit | Protein Jagged-1 (JAG1) | Unconjugated | ELISA, IHC | 250 | 50 µl | P78504 | RUO | |
Abbexa | JAG1 | abx214943 | Protein Jagged-1 (JAG1) Antibody | Human | Polyclonal | Rabbit | Protein Jagged-1 (JAG1) | Unconjugated | ELISA, IHC | 250 | 50 µl | P78504 | RUO | |
Abbexa | JAG1 | abx327592 | Protein Jagged-1 (JAG1) Antibody | Human | Polyclonal | Rabbit | Protein Jagged-1 (JAG1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P78504 | RUO | |
Abbexa | JAG1 | abx129567 | Jagged 1 Protein (JAG1) Antibody | Mouse | Polyclonal | Rabbit | Jagged 1 Protein (JAG1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9QXX0 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | JAG1 | abx654085 | Mouse Jagged 1 Protein (JAG1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | RUO | |
Abbexa | JAG1 | abx165879 | Mouse Jagged 1 Protein (JAG1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | RUO | |
Abbexa | JAG1 | abx067572 | Human Jagged 1 Protein (JAG1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | P78504 | RUO |
Abbexa | JAG1 | abx067570 | Human Jagged 1 Protein (JAG1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | P78504 | RUO |
Abbexa | JAG1 | abx067571 | Human Jagged 1 Protein (JAG1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | P78504 | RUO |
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