Rat Protein jagged-1 (JAG1) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for JAG1
proveedor
Abbexareference
abx256614Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Protein jagged-1 (JAG1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Protein jagged-1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Jagged-1 (JAG1) is a critical ligand within the Notch signaling pathway, a key cell-to-cell communication mechanism that regulates cellular differentiation, proliferation, and apoptosis. This pathway is pivotal during embryonic development and maintains tissue homeostasis in adults. JAG1, specifically, is one of the five canonical Notch ligands (alongside JAG2, DLL1, DLL3, and DLL4) and is highly involved in multiple developmental processes such as neurogenesis, vasculogenesis, and skeletal development. The interaction of JAG1 with Notch receptors triggers a series of proteolytic cleavages and releases the Notch intracellular domain (NICD), which translocates to the nucleus and activates target gene transcription. Dysregulation of JAG1 or aberrations in the Notch pathway are linked to congenital disorders, cancers, and other pathological conditions. In particular, mutations in JAG1 are associated with Alagille syndrome, a multisystem disorder affecting the liver, heart, and other organs.
Características del producto
category
ELISA Kits
immunogen target
Protein jagged-1 (JAG1)
reactivity
Rat
test range
78 pg/ml - 5000 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
Protein jagged-1,AGS,AHD,AWS,HJ1,AGS1,DCHE,CD339,JAGL1,CMT2HH,Jagged1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
JAG1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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