Human Jagged 1 Protein (JAG1) ELISA Kit
643.5€ (96 tests)
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name
Human Jagged 1 Protein (JAG1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx152071
tested applications
ELISA
Description
Human Jagged 1 Protein (JAG1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Jagged 1 Protein (JAG1) concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Jagged 1 Protein (JAG1)
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Jagged 1 Protein (JAG1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | Protein jagged-1,AGS,AHD,AWS,HJ1,AGS1,DCHE,CD339,JAGL1,CMT2HH,Jagged1 |
| Background | Elisa Kits for: JAG1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
Jagged-1 (JAG1) is a critical ligand within the Notch signaling pathway, a key cell-to-cell communication mechanism that regulates cellular differentiation, proliferation, and apoptosis. This pathway is pivotal during embryonic development and maintains tissue homeostasis in adults. JAG1, specifically, is one of the five canonical Notch ligands (alongside JAG2, DLL1, DLL3, and DLL4) and is highly involved in multiple developmental processes such as neurogenesis, vasculogenesis, and skeletal development. The interaction of JAG1 with Notch receptors triggers a series of proteolytic cleavages and releases the Notch intracellular domain (NICD), which translocates to the nucleus and activates target gene transcription. Dysregulation of JAG1 or aberrations in the Notch pathway are linked to congenital disorders, cancers, and other pathological conditions. In particular, mutations in JAG1 are associated with Alagille syndrome, a multisystem disorder affecting the liver, heart, and other organs.
