Human Jagged 1 Protein (JAG1) Protein

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935106861
info@markelab.com
Precio
208€ (10 µg)
Protein JAG1
proveedor
Abbexareference
abx067571Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Jagged 1 Protein (JAG1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
Jagged-1 (JAG1) is a critical ligand within the Notch signaling pathway, a key cell-to-cell communication mechanism that regulates cellular differentiation, proliferation, and apoptosis. This pathway is pivotal during embryonic development and maintains tissue homeostasis in adults. JAG1, specifically, is one of the five canonical Notch ligands (alongside JAG2, DLL1, DLL3, and DLL4) and is highly involved in multiple developmental processes such as neurogenesis, vasculogenesis, and skeletal development. The interaction of JAG1 with Notch receptors triggers a series of proteolytic cleavages and releases the Notch intracellular domain (NICD), which translocates to the nucleus and activates target gene transcription. Dysregulation of JAG1 or aberrations in the Notch pathway are linked to congenital disorders, cancers, and other pathological conditions. In particular, mutations in JAG1 are associated with Alagille syndrome, a multisystem disorder affecting the liver, heart, and other organs.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Jagged 1 Protein (JAG1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 40.7 kDa Observed MW: 45 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly470-Thr834 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
JAG1
dry ice
No
availability
Shipped within 5-7 working days.
alias
Protein jagged-1,AGS,AHD,AWS,HJ1,AGS1,DCHE,CD339,JAGL1,CMT2HH,Jagged1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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