Human Jagged 1 Protein (JAG1) Protein

Este producto es parte de JAG1 - jagged canonical Notch ligand 1
Human Jagged 1 Protein (JAG1) Protein

Pida mas información

935106861

info@markelab.com

Precio

208€ (10 µg)

Protein JAG1

proveedor

Abbexa

reference

abx067570

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Jagged 1 Protein (JAG1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Jagged-1 (JAG1) is a critical ligand within the Notch signaling pathway, a key cell-to-cell communication mechanism that regulates cellular differentiation, proliferation, and apoptosis. This pathway is pivotal during embryonic development and maintains tissue homeostasis in adults. JAG1, specifically, is one of the five canonical Notch ligands (alongside JAG2, DLL1, DLL3, and DLL4) and is highly involved in multiple developmental processes such as neurogenesis, vasculogenesis, and skeletal development. The interaction of JAG1 with Notch receptors triggers a series of proteolytic cleavages and releases the Notch intracellular domain (NICD), which translocates to the nucleus and activates target gene transcription. Dysregulation of JAG1 or aberrations in the Notch pathway are linked to congenital disorders, cancers, and other pathological conditions. In particular, mutations in JAG1 are associated with Alagille syndrome, a multisystem disorder affecting the liver, heart, and other organs.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Jagged 1 Protein (JAG1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 25.6 kDa Observed MW: 28 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly33-Asp250 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

JAG1


dry ice

No


availability

Shipped within 5-7 working days.


alias

Protein jagged-1,AGS,AHD,AWS,HJ1,AGS1,DCHE,CD339,JAGL1,CMT2HH,Jagged1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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