Protein Jagged-1 (JAG1) Antibody
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Pida mas información
935106861
info@markelab.com
Precio
357.5€ (100 µg)
Antibody anti-JAG1
proveedor
Abbexareference
abx038125Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
Rabbit Polyclonal against the JAG1 protein.
Background
Jagged-1 (JAG1) is a critical ligand within the Notch signaling pathway, a key cell-to-cell communication mechanism that regulates cellular differentiation, proliferation, and apoptosis. This pathway is pivotal during embryonic development and maintains tissue homeostasis in adults. JAG1, specifically, is one of the five canonical Notch ligands (alongside JAG2, DLL1, DLL3, and DLL4) and is highly involved in multiple developmental processes such as neurogenesis, vasculogenesis, and skeletal development. The interaction of JAG1 with Notch receptors triggers a series of proteolytic cleavages and releases the Notch intracellular domain (NICD), which translocates to the nucleus and activates target gene transcription. Dysregulation of JAG1 or aberrations in the Notch pathway are linked to congenital disorders, cancers, and other pathological conditions. In particular, mutations in JAG1 are associated with Alagille syndrome, a multisystem disorder affecting the liver, heart, and other organs.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Protein Jagged-1 (JAG1)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Lyophilized
tested applications
ELISA, WB
purification
Purified by Protein A/G column chromatography.
recommended dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
buffer
Prior to lyophilization: 0.02% NaN3.
size 1
100 µg
size 2
1 mg
storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
or code
JAG1
dry ice
No
availability
Shipped within 7-15 working days.
alias
Protein jagged-1,AGS,AHD,AWS,HJ1,AGS1,DCHE,CD339,JAGL1,CMT2HH,Jagged1
note
Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. -
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