Family main features
CLEC4D, known as C-type lectin domain family 4 member D, also referred to as macrophage-inducible C-type lectin (Mincle), is a receptor primarily expressed on immune cells, particularly macrophages and neutrophils. CLEC4D is part of the C-type lectin receptor (CLR) family, which is involved in recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). These receptors play critical roles in the innate immune response by recognizing carbohydrate structures on pathogens or damaged cells, thus initiating immune responses to eliminate infections or maintain immune homeostasis.
CLEC4D functions primarily as an activating receptor and is involved in inflammation and immune activation, particularly in response to microbial infections and tissue damage. Its role in recognizing non-self and modified-self molecules underscores its importance in immunity. CLEC4D’s interaction with mycobacterial glycolipids, fungal pathogens, and endogenous ligands positions it as an essential component of innate immune defenses, especially in fungal and bacterial infections. Furthermore, CLEC4D’s involvement in sterile inflammatory responses has expanded its relevance to non-infectious diseases, including tissue injury and autoimmune conditions.
CLEC4D has a structural layout characteristic of type II transmembrane proteins in the C-type lectin receptor family:
Extracellular C-type Lectin-like Domain (CTLD):
Stalk Region:
Transmembrane Domain:
Cytoplasmic Tail:
CLEC4D belongs to the C-type lectin domain family 4 (CLEC4), specifically the subgroup of receptors involved in pathogen recognition and immune activation. It is often grouped within the dectin-like family of receptors due to its role in pathogen recognition and signaling through ITAM motifs. CLEC4D does not have well-characterized subtypes or isoforms, and it functions distinctly in innate immunity. Other members in the CLEC4 family, such as CLEC4E (dectin-2) and CLEC4A (DCIR), have varied functions but often share overlapping roles in recognizing carbohydrate patterns on pathogens.
CLEC4D plays a central role in pathogen detection, immune activation, and inflammation. Its major functions include:
Pathogen Recognition and Binding:
Activation of Innate Immune Responses:
Role in Sterile Inflammation:
Crosstalk with Adaptive Immunity:
CLEC4D’s involvement in immune responses links it to various clinical conditions:
Infectious Diseases:
Inflammatory and Autoimmune Diseases:
Sterile Inflammatory Responses:
Cancer:
CLEC4D is a critical C-type lectin receptor with significant roles in innate immunity, pathogen recognition, and inflammatory responses. Its structure includes an extracellular C-type lectin-like domain for carbohydrate binding, a transmembrane domain for membrane anchoring, and an association with the Fc receptor γ-chain for intracellular signaling. CLEC4D is particularly involved in recognizing fungal and bacterial pathogens, facilitating immune activation through cytokine production and the recruitment of immune cells.
The biological significance of CLEC4D extends beyond pathogen recognition to sterile inflammation, where it responds to tissue injury, contributing to immune responses that clear damaged cells and facilitate repair. Clinically, CLEC4D’s function has implications in infectious diseases, autoimmune conditions, inflammatory disorders, and potentially cancer. Its ability to modulate inflammation and immunity makes it a promising target for therapeutic intervention, with research exploring its modulation to treat infections, inflammation, and possibly enhance antitumor immunity. CLEC4D’s unique role in recognizing both pathogenic and endogenous ligands underscores its importance in maintaining immune homeostasis and responding to pathological conditions.
C-type lectin domain family 4 member D (CLEC4D)
C-type lectin superfamily member 8,MCL,MPCL,CD368,CLEC6,CLEC-6,CLECSF8,Dectin-3,C-type lectin-like receptor 6,Dendritic cell-associated C-type lectin 3
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con CLEC4D - C-type lectin domain family 4 member D
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Esta página contiene 15 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | CLEC4D | abx386566 | Human C-Type Lectin Domain Family 4 Member D (CLEC4D) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | Q8WXI8 | RUO |
Abbexa | CLEC4D | abx507130 | Mouse C-type lectin domain family 4 member D (CLEC4D) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9Z2H6 | RUO | ||
Abbexa | CLEC4D | abx507131 | Rat C-Type Lectin Domain Family 4 Member D (CLEC4D) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q69FH1 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | CLEC4D | FNab01754 | anti- CLEC4D antibody | human | polyclonal | Rabbit | C-type lectin domain family 4, member D | IgG | Unconjugated | ELISA, IHC | 100µg | Q8WXI8 | RUO | |
Abbexa | CLEC4D | abx309494 | C-Type Lectin Domain Family 4 Member D (CLEC4D) Antibody (FITC) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member D (CLEC4D) | FITC | 162.5 | 20 µg | Q8WXI8 | RUO | ||
Abbexa | CLEC4D | abx309493 | C-Type Lectin Domain Family 4 Member D (CLEC4D) Antibody (HRP) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member D (CLEC4D) | HRP | ELISA | 162.5 | 20 µg | Q8WXI8 | RUO | |
Abbexa | CLEC4D | abx029587 | C-Type Lectin Domain Family 4 Member D (CLEC4D) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member D (CLEC4D) | Unconjugated | ELISA, WB | 250 | 80 µl | Q8WXI8 | RUO | |
Abbexa | CLEC4D | abx309495 | C-Type Lectin Domain Family 4 Member D (CLEC4D) Antibody (Biotin) | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member D (CLEC4D) | Biotin | ELISA | 162.5 | 20 µg | Q8WXI8 | RUO | |
Abbexa | CLEC4D | abx301556 | C-Type Lectin Domain Family 4 Member D (CLEC4D) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member D (CLEC4D) | Unconjugated | ELISA, IHC | 162.5 | 20 µg | Q8WXI8 | RUO | |
Abbexa | CLEC4D | abx211319 | C-Type Lectin Domain Family 4 Member D (CLEC4D) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member D (CLEC4D) | Unconjugated | ELISA, WB | 250 | 50 µl | Q8WXI8 | RUO | |
Abbexa | CLEC4D | abx231754 | C-Type Lectin Domain Family 4 Member D (CLEC4D) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member D (CLEC4D) | Unconjugated | ELISA, IHC | 350 | 100 µg | Q8WXI8 | RUO | |
Abbexa | CLEC4D | abx002061 | C-Type Lectin Domain Family 4 Member D (CLEC4D) Antibody | Human | Polyclonal | Rabbit | C-Type Lectin Domain Family 4 Member D (CLEC4D) | Unconjugated | WB, IF/ICC | 175 | 20 µl | Q8WXI8 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CLEC4D | abx693426 | Rat C-Type Lectin Domain Family 4 Member D (CLEC4D) Protein | Rat | Recombinant | HEK293 cells | SDS-PAGE | 962.5 | 100 µg | Q69FH1 | RUO | |
Abbexa | CLEC4D | abx693301 | Human C-Type Lectin Domain Family 4 Member D (CLEC4D) Protein | Human | Recombinant | HEK293 cells | SDS-PAGE | 962.5 | 100 µg | RUO | ||
Abbexa | CLEC4D | abx693065 | Rat C-Type Lectin Domain Family 4 Member D (CLEC4D) Protein | Rat | Recombinant | HEK293 cells | SDS-PAGE | 962.5 | 100 µg | Q69FH1 | RUO |
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