C-Type Lectin Domain Family 4 Member D (CLEC4D) Antibody
377€ (100 µg)
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Name
C-Type Lectin Domain Family 4 Member D (CLEC4D) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx231754
Tested Applications
ELISA, IHC
Description
CLEC4D Antibody is a Rabbit Polyclonal against CLEC4D.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: C-Type Lectin Domain Family 4 Member D (CLEC4D) Immunogen: C-type lectin domain family 4, member D |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WXI8 |
| Gene ID | 338339 |
| OMIM | 609964 |
| Alias | C-type lectin superfamily member 8,MCL,MPCL,CD368,CLEC6,CLEC-6,CLECSF8,Dectin-3,C-type lectin-like receptor 6,Dendritic cell-associated C-type lectin 3 |
| Background | Antibody anti-CLEC4D |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CLEC4D, known as C-type lectin domain family 4 member D, also referred to as macrophage-inducible C-type lectin (Mincle), is a receptor primarily expressed on immune cells, particularly macrophages and neutrophils. CLEC4D is part of the C-type lectin receptor (CLR) family, which is involved in recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). These receptors play critical roles in the innate immune response by recognizing carbohydrate structures on pathogens or damaged cells, thus initiating immune responses to eliminate infections or maintain immune homeostasis. CLEC4D functions primarily as an activating receptor and is involved in inflammation and immune activation, particularly in response to microbial infections and tissue damage. Its role in recognizing non-self and modified-self molecules underscores its importance in immunity. CLEC4D’s interaction with mycobacterial glycolipids, fungal pathogens, and endogenous ligands positions it as an essential component of innate immune defenses, especially in fungal and bacterial infections. Furthermore, CLEC4D’s involvement in sterile inflammatory responses has expanded its relevance to non-infectious diseases, including tissue injury and autoimmune conditions.
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