Family main features
Cadherin 1 (CDH1), also known as E-cadherin (epithelial cadherin), is a transmembrane glycoprotein primarily responsible for cell-cell adhesion in epithelial tissues. It is a crucial member of the cadherin superfamily, a group of calcium-dependent adhesion molecules that mediate homophilic binding interactions between cells. CDH1 is indispensable for maintaining cellular architecture and tissue integrity, especially within epithelial layers, where it anchors cells to each other, forming adherens junctions that maintain cellular polarity and tissue structure. CDH1 also plays a significant role in regulating signaling pathways involved in cell differentiation, proliferation, and survival.
The biological significance of CDH1 extends to tumor suppression, as its presence prevents detachment of cells from the epithelial layer, which could otherwise lead to metastasis. Loss or downregulation of CDH1 is frequently observed in various cancers, particularly in those characterized by epithelial-mesenchymal transition (EMT), a process by which epithelial cells acquire migratory and invasive properties. Therefore, CDH1 is not only integral to tissue integrity but also to preventing disease progression, especially in oncogenesis.
The CDH1 protein is a type I transmembrane glycoprotein that contains several distinct structural regions:
Extracellular Domain:
Transmembrane Domain:
Cytoplasmic Domain:
Calcium-Binding Sites:
CDH1 belongs to the classical cadherins subgroup within the larger cadherin superfamily. Classical cadherins are generally characterized by five extracellular cadherin repeats and a conserved cytoplasmic domain that interacts with catenins. CDH1 specifically falls under type I cadherins, known for their essential role in forming adherens junctions in epithelial cells. While CDH1 (E-cadherin) is primarily found in epithelial tissues, other classical cadherins, such as N-cadherin (CDH2) and P-cadherin (CDH3), are expressed in neuronal and placental tissues, respectively, highlighting a degree of tissue specificity among cadherins.
The primary function of CDH1 is mediating cell-cell adhesion in epithelial tissues, forming the basis of adherens junctions that maintain tissue architecture and cellular polarity. Its functions and significance are outlined below:
Cell Adhesion and Tissue Integrity:
Cell Polarity and Differentiation:
Signal Transduction and Gene Regulation:
Tumor Suppression and EMT Inhibition:
Mutations or downregulation of CDH1 are implicated in various diseases, most notably cancer. Clinical issues associated with CDH1 include:
Hereditary Diffuse Gastric Cancer (HDGC):
Cancer Metastasis:
Inflammatory Diseases:
Congenital Abnormalities:
CDH1 (E-cadherin) is a calcium-dependent cell adhesion protein essential for maintaining cell-cell adhesion, tissue integrity, and cellular polarity in epithelial tissues. Structurally, CDH1 consists of five extracellular cadherin repeats that bind calcium ions, a transmembrane domain, and a cytoplasmic domain that interacts with catenins, linking it to the actin cytoskeleton. Through homophilic interactions, CDH1 forms adherens junctions that stabilize tissue architecture and support epithelial polarity. Its functions extend to regulating gene transcription by sequestering β-catenin at the cell membrane, preventing pro-tumorigenic signaling.
Clinically, CDH1 is a key tumor suppressor, and its downregulation is associated with EMT and metastasis in several cancers, including breast and gastric cancers. Mutations in the CDH1 gene are implicated in hereditary diffuse gastric cancer and lobular breast cancer, prompting genetic screening and preventive measures in high-risk individuals. Loss of CDH1 function is a hallmark of aggressive cancers and a prognostic indicator in oncology. Additionally, CDH1 dysfunction is associated with inflammatory diseases and developmental abnormalities. The critical role of CDH1 in cell adhesion and tumor suppression underscores its importance in maintaining epithelial integrity and preventing oncogenic progression, making it a significant target in cancer diagnostics and therapeutics.
cadherin 1 (CDH1)
Uvomorulin,UVO,CDHE,ECAD,LCAM,Arc-1,BCDS1,CD324,CAM 120/80,Epithelial cadherin
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con CDH1 - cadherin 1
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 44 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CDH1 | abx354657 | Chicken Cadherin-1 / E-Cadherin (CDH1) ELISA Kit | Chicken | Serum,Plasma,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | CDH1 | abx573670 | Cow Cadherin-1 / E-Cadherin (CDH1) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | < 0.078 ng/ml | 687.5 | 96 tests | Q6R8F2 | RUO | |
Abbexa | CDH1 | abx195397 | Human Cadherin-1 / E-Cadherin (CDH1) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | CDH1 | abx195398 | Mouse Cadherin-1 / E-Cadherin (CDH1) CLIA Kit | Mouse | Serum, plasma and other biological fluids. | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | CDH1 | abx573517 | Pig Cadherin-1 / E-Cadherin (CDH1) ELISA Kit | Pig | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.781 ng/ml - 50 ng/ml | < 0.195 ng/ml | 675 | 96 tests | C6EVT4 | RUO |
Abbexa | CDH1 | abx195399 | Rat Cadherin-1 / E-Cadherin (CDH1) CLIA Kit | Rat | Serum, plasma and other biological fluids. | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 618.75 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CDH1 | abx341482 | Cadherin-1 (CDH1) Antibody | Human | Polyclonal | Rabbit | Cadherin-1 (CDH1) | Unconjugated | ELISA, WB, IHC, IF/ICC, IP | 162.5 | 20 µg | P12830 | RUO | |
Abbexa | CDH1 | abx334887 | Cadherin-1 / E-Cadherin (CDH1) Antibody (HRP) | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | HRP | ELISA | 162.5 | 20 µg | P12830 | RUO | |
Abbexa | CDH1 | abx139348 | Cadherin-1 / E-Cadherin (CDH1) Antibody (PE) | Human | Monoclonal | Mouse | Cadherin-1 / E-Cadherin (CDH1) | PE | FCM | 400 | 100 tests | P12830 | RUO | |
Abbexa | CDH1 | abx341083 | Cadherin-1 (CDH1) Antibody | Human | Monoclonal | Mouse | Cadherin-1 (CDH1) | Unconjugated | ELISA, IHC | 250 | 50 µl | P12830 | RUO | |
Abbexa | CDH1 | abx341484 | Cadherin-1 (CDH1) Antibody (FITC) | Human | Polyclonal | Rabbit | Cadherin-1 (CDH1) | FITC | 162.5 | 20 µg | P12830 | RUO | ||
Abbexa | CDH1 | abx334889 | Cadherin-1 / E-Cadherin (CDH1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Biotin | ELISA | 162.5 | 20 µg | P12830 | RUO | |
Abbexa | CDH1 | abx341485 | Cadherin-1 (CDH1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Cadherin-1 (CDH1) | Biotin | ELISA | 162.5 | 20 µg | P12830 | RUO | |
Abbexa | CDH1 | abx125643 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | WB | 175 | 20 µl | P12830 | RUO | |
Abbexa | CDH1 | abx139349 | Cadherin-1 / E-Cadherin (CDH1) Antibody (APC) | Human | Monoclonal | Mouse | Cadherin-1 / E-Cadherin (CDH1) | APC | FCM | 400 | 100 tests | P12830 | RUO | |
Abbexa | CDH1 | abx139347 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Monoclonal | Mouse | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | WB, IHC-F, IF/ICC, FCM, IP | 325 | 0.1 mg | P12830 | RUO | |
Abbexa | CDH1 | abx333963 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | P12830 | RUO | |
Abbexa | CDH1 | abx341483 | Cadherin-1 (CDH1) Antibody (HRP) | Human | Polyclonal | Rabbit | Cadherin-1 (CDH1) | HRP | ELISA | 162.5 | 20 µg | P12830 | RUO | |
Abbexa | CDH1 | abx324914 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 187.5 | 50 µg | P12830 | RUO | |
Abbexa | CDH1 | abx334888 | Cadherin-1 / E-Cadherin (CDH1) Antibody (FITC) | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | FITC | 162.5 | 20 µg | P12830 | RUO | ||
Abbexa | CDH1 | abx034894 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Monoclonal | Mouse | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | ELISA, WB | 525 | 100 µl | P12830 | RUO | |
Abbexa | CDH1 | abx323246 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | WB, IHC | 187.5 | 50 µg | P12830 | RUO | |
Abbexa | CDH1 | abx038132 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | CDH1 | abx227144 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Monoclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | IHC | 262.5 | 40 µl | P12830 | RUO | |
Abbexa | CDH1 | abx402312 | Cadherin-1 (CDH1) Antibody | Human | Monoclonal | Rabbit | Cadherin-1 (CDH1) | Unconjugated | ELISA, IHC | 287.5 | 50 µl | P12830 | RUO | |
Abbexa | CDH1 | abx034792 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Monoclonal | Mouse | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | P12830 | RUO | |
Abbexa | CDH1 | abx341036 | Cadherin-1 (CDH1) Antibody | Human | Monoclonal | Mouse | Cadherin-1 (CDH1) | Unconjugated | ELISA, WB, IF/ICC, FCM | 287.5 | 50 µl | P12830 | RUO | |
Abbexa | CDH1 | abx002199 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | WB, IHC | 175 | 20 µl | P12830 | RUO | |
Abbexa | CDH1 | abx349878 | Cadherin-1 (CDH1) Antibody | Human | Monoclonal | Mouse | Cadherin-1 (CDH1) | Unconjugated | ELISA, WB, IHC, FCM | 287.5 | 50 µl | P12830 | RUO | |
Abbexa | CDH1 | abx125645 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | WB | 175 | 20 µl | P12830 | RUO | |
Abbexa | CDH1 | abx015807 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Monoclonal | Mouse | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | ELISA, WB | 362.5 | 100 µl | RUO | ||
Abbexa | CDH1 | abx012163 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Monoclonal | Mouse | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | ELISA, WB, IHC, FCM | 362.5 | 100 µl | P12830 | RUO | |
Abbexa | CDH1 | abx111290 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | ELISA, WB, IF/ICC | 612.5 | 100 µl | P12830 | RUO | |
Abbexa | CDH1 | abx002263 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Monoclonal | Mouse | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | IHC | 212.5 | 20 µl | P09803 | RUO | |
Abbexa | CDH1 | abx125644 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | P12830 | RUO | |
Abbexa | CDH1 | abx240004 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Monoclonal | Mouse | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 350 | 100 µg | P12830 | RUO | |
Abbexa | CDH1 | abx241406 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | ELISA, IHC | 250 | 50 µl | P12830 | RUO | |
Abbexa | CDH1 | abx241053 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P12830 | RUO | |
Abbexa | CDH1 | abx214985 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | P12830 | RUO | |
Abbexa | CDH1 | abx241405 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Polyclonal | Rabbit | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | ELISA, IHC | 250 | 50 µl | P12830 | RUO | |
Abbexa | CDH1 | abx432231 | Cadherin-1 / E-Cadherin (CDH1) Antibody | Human | Polyclonal | Goat | Cadherin-1 / E-Cadherin (CDH1) | Unconjugated | P-ELISA, WB, IHC | 387.5 | 200 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CDH1 | abx680182 | Human Cadherin-1 / E-Cadherin (CDH1) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 225 | 2 µg | RUO | |
Abbexa | CDH1 | abx680527 | Human Cadherin-1 (CDH1) Protein | Human | Recombinant | HEK293 cells | Unconjugated | SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | CDH1 | abx694300 | Rat Cadherin-1 (CDH1) Protein | Rat | Recombinant | HEK293 cells | SDS-PAGE | 300 | 20 µg | Q9R0T4 | RUO |
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