Cadherin-1 / E-Cadherin (CDH1) Antibody (PE)
Pida mas información
935106861
info@markelab.com
Precio
400€ (100 tests)
Antibody anti-CDH1
proveedor
Abbexareference
abx139348Tested Applications
FCMreactivity
Humanstatus
RUOclonality
MonoclonalDescripción
CD324 Antibody is a Mouse Monoclonal against CD324.
Background
Cadherin 1 (CDH1), also known as E-cadherin (epithelial cadherin), is a transmembrane glycoprotein primarily responsible for cell-cell adhesion in epithelial tissues. It is a crucial member of the cadherin superfamily, a group of calcium-dependent adhesion molecules that mediate homophilic binding interactions between cells. CDH1 is indispensable for maintaining cellular architecture and tissue integrity, especially within epithelial layers, where it anchors cells to each other, forming adherens junctions that maintain cellular polarity and tissue structure. CDH1 also plays a significant role in regulating signaling pathways involved in cell differentiation, proliferation, and survival. The biological significance of CDH1 extends to tumor suppression, as its presence prevents detachment of cells from the epithelial layer, which could otherwise lead to metastasis. Loss or downregulation of CDH1 is frequently observed in various cancers, particularly in those characterized by epithelial-mesenchymal transition (EMT), a process by which epithelial cells acquire migratory and invasive properties. Therefore, CDH1 is not only integral to tissue integrity but also to preventing disease progression, especially in oncogenesis.
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human
immunogen target
Cadherin-1 / E-Cadherin (CDH1)
host
Mouse
conjugation
PE
tested applications
FCM
buffer
Stabilizing PBS solution containing 15 mM sodium azide.
size 1
100 tests
storage
Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze.
or code
CDH1
dry ice
No
availability
Shipped within 5-12 working days.
alias
Uvomorulin,UVO,CDHE,ECAD,LCAM,Arc-1,BCDS1,CD324,CAM 120/80,Epithelial cadherin
uniprot id
note
This product is for research use only.
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