Cadherin-1 / E-Cadherin (CDH1) Antibody (PE)

Este producto es parte de CDH1 - cadherin 1
Cadherin-1 / E-Cadherin (CDH1) Antibody (PE)

Pida mas información

935106861

info@markelab.com

Precio

400€ (100 tests)

Antibody anti-CDH1

proveedor

Abbexa

reference

abx139348

Tested Applications

FCM

reactivity

Human

status

RUO

clonality

Monoclonal

Descripción

CD324 Antibody is a Mouse Monoclonal against CD324.


Background

Cadherin 1 (CDH1), also known as E-cadherin (epithelial cadherin), is a transmembrane glycoprotein primarily responsible for cell-cell adhesion in epithelial tissues. It is a crucial member of the cadherin superfamily, a group of calcium-dependent adhesion molecules that mediate homophilic binding interactions between cells. CDH1 is indispensable for maintaining cellular architecture and tissue integrity, especially within epithelial layers, where it anchors cells to each other, forming adherens junctions that maintain cellular polarity and tissue structure. CDH1 also plays a significant role in regulating signaling pathways involved in cell differentiation, proliferation, and survival. The biological significance of CDH1 extends to tumor suppression, as its presence prevents detachment of cells from the epithelial layer, which could otherwise lead to metastasis. Loss or downregulation of CDH1 is frequently observed in various cancers, particularly in those characterized by epithelial-mesenchymal transition (EMT), a process by which epithelial cells acquire migratory and invasive properties. Therefore, CDH1 is not only integral to tissue integrity but also to preventing disease progression, especially in oncogenesis.

Características del producto

category

Primary Antibodies


clonality

Monoclonal


reactivity

Human


immunogen target

Cadherin-1 / E-Cadherin (CDH1)


host

Mouse


conjugation

PE


tested applications

FCM


buffer

Stabilizing PBS solution containing 15 mM sodium azide.


size 1

100 tests


storage

Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze.


or code

CDH1


dry ice

No


availability

Shipped within 5-12 working days.


alias

Uvomorulin,UVO,CDHE,ECAD,LCAM,Arc-1,BCDS1,CD324,CAM 120/80,Epithelial cadherin 


note

This product is for research use only.


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