CDH1 antibody

Este producto es parte de CDH1 - cadherin 1
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935106861
info@markelab.com
name
CDH1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab10112
tested applications
ELISA, IHC, WB, IF

Description

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
cadherin 1, type 1, E-cadherin (epithelial) (CDH1)
Host
Mouse
Reactivity
Human
Recommended Dilution
WB: 1:1000-1:5000; IHC: 1:500-1:2000; IF: 1:50-1:500
Clonality
monoclonal
Conjugation
Unconjugated
Isotype
IgG2b
Clone ID
3G10
Observed MW
130 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
protein A+G purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, IHC, WB, IF
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P12830
Gene ID
999
Alias
Uvomorulin,UVO,CDHE,ECAD,LCAM,Arc-1,BCDS1,CD324,CAM 120/80,Epithelial cadherin
Background
Antibody anti-CDH1
Status
RUO
Note
Mol. Weight 130 kDa

Descripción

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