CDH1 antibody

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935106861
info@markelab.com
name
CDH1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab10112
tested applications
ELISA, IHC, WB, IF
Description
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | cadherin 1, type 1, E-cadherin (epithelial) (CDH1) |
Host | Mouse |
Reactivity | Human |
Recommended Dilution | WB: 1:1000-1:5000; IHC: 1:500-1:2000; IF: 1:50-1:500 |
Clonality | monoclonal |
Conjugation | Unconjugated |
Isotype | IgG2b |
Clone ID | 3G10 |
Observed MW | 130 kDa |
Purity | ≥95% as determined by SDS-PAGE |
Purification | protein A+G purified |
Size 1 | 100µg |
Form | liquid |
Tested Applications | ELISA, IHC, WB, IF |
Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
UniProt ID | P12830 |
Gene ID | 999 |
Alias | Uvomorulin,UVO,CDHE,ECAD,LCAM,Arc-1,BCDS1,CD324,CAM 120/80,Epithelial cadherin |
Background | Antibody anti-CDH1 |
Status | RUO |
Note | Mol. Weight 130 kDa |
Descripción
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