Human Cadherin-1 / E-Cadherin (CDH1) Protein
234€ (2 µg)
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935106861
info@markelab.com
name
Human Cadherin-1 / E-Cadherin (CDH1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx680182
tested applications
SDS-PAGE
Description
Human Cadherin-1 / E-Cadherin (CDH1) Protein is a recombinant protein produced in Sf9, Baculovirus cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Cadherin-1 / E-Cadherin (CDH1) |
| Host | Insect |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | Uvomorulin,UVO,CDHE,ECAD,LCAM,Arc-1,BCDS1,CD324,CAM 120/80,Epithelial cadherin |
| Background | Protein CDH1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Cadherin 1 (CDH1), also known as E-cadherin (epithelial cadherin), is a transmembrane glycoprotein primarily responsible for cell-cell adhesion in epithelial tissues. It is a crucial member of the cadherin superfamily, a group of calcium-dependent adhesion molecules that mediate homophilic binding interactions between cells. CDH1 is indispensable for maintaining cellular architecture and tissue integrity, especially within epithelial layers, where it anchors cells to each other, forming adherens junctions that maintain cellular polarity and tissue structure. CDH1 also plays a significant role in regulating signaling pathways involved in cell differentiation, proliferation, and survival. The biological significance of CDH1 extends to tumor suppression, as its presence prevents detachment of cells from the epithelial layer, which could otherwise lead to metastasis. Loss or downregulation of CDH1 is frequently observed in various cancers, particularly in those characterized by epithelial-mesenchymal transition (EMT), a process by which epithelial cells acquire migratory and invasive properties. Therefore, CDH1 is not only integral to tissue integrity but also to preventing disease progression, especially in oncogenesis.
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