Cadherin-1 / E-Cadherin (CDH1) Antibody

Este producto es parte de CDH1 - cadherin 1
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195€ (20 µl)

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935106861
info@markelab.com
name
Cadherin-1 / E-Cadherin (CDH1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx002199
tested applications
ELISA, WB, IHC

Description

CDH1 Antibody is a Rabbit Polyclonal antibody against CDH1. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008].

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Product specifications

CategoryPrimary Antibodies
Immunogen TargetCadherin-1 / E-Cadherin (CDH1)
HostRabbit
ReactivityHuman, Mouse, Rat
Recommended DilutionELISA: 1 µg/ml, WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationPurified by affinity chromatography.
Size 120 µl
Size 2100 µl
Size 32 × 100 µl
FormLiquid
Tested ApplicationsELISA, WB, IHC
BufferPBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP12830
Gene ID999
NCBI AccessionNP_004351.1
AliasUvomorulin,UVO,CDHE,ECAD,LCAM,Arc-1,BCDS1,CD324,CAM 120/80,Epithelial cadherin
BackgroundAntibody anti-CDH1
StatusRUO
NoteConcentration: 0.53 mg/ml -

Descripción

Cadherin 1 (CDH1), also known as E-cadherin (epithelial cadherin), is a transmembrane glycoprotein primarily responsible for cell-cell adhesion in epithelial tissues. It is a crucial member of the cadherin superfamily, a group of calcium-dependent adhesion molecules that mediate homophilic binding interactions between cells. CDH1 is indispensable for maintaining cellular architecture and tissue integrity, especially within epithelial layers, where it anchors cells to each other, forming adherens junctions that maintain cellular polarity and tissue structure. CDH1 also plays a significant role in regulating signaling pathways involved in cell differentiation, proliferation, and survival. The biological significance of CDH1 extends to tumor suppression, as its presence prevents detachment of cells from the epithelial layer, which could otherwise lead to metastasis. Loss or downregulation of CDH1 is frequently observed in various cancers, particularly in those characterized by epithelial-mesenchymal transition (EMT), a process by which epithelial cells acquire migratory and invasive properties. Therefore, CDH1 is not only integral to tissue integrity but also to preventing disease progression, especially in oncogenesis.

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