Family main features
CDCP1 (CUB Domain Containing Protein 1), also known as CD318 or Trask, is a transmembrane protein widely expressed across cell types, including epithelial cells, stem cells, and notably in certain types of cancer cells. CDCP1 is known for its involvement in various cellular processes, including cell adhesion, migration, and signal transduction. It is a single-pass membrane protein characterized by extracellular CUB domains, which are implicated in protein-protein interactions, especially in cell communication and adhesion mechanisms.
CDCP1 plays a crucial role in cancer biology, as its overexpression or aberrant activation has been observed in multiple malignancies, such as lung, colon, and breast cancer, where it contributes to processes like invasion, metastasis, and resistance to apoptosis. This makes CDCP1 an important molecule in cancer progression and a potential target for therapeutic interventions. Moreover, CDCP1 is implicated in non-cancerous biological pathways, including wound healing and tissue remodeling, which involve dynamic changes in cell adhesion and migration.
CDCP1 is a type I transmembrane protein with a complex structure that is essential for its functions:
Extracellular Domain:
Transmembrane Domain:
Intracellular (Cytoplasmic) Domain:
CDCP1 belongs to a family of CUB domain-containing proteins. These proteins are involved in diverse cellular functions, including development, tissue remodeling, and immune responses, largely due to their interactions with ECM components and other cell surface proteins. Although no specific subtypes of CDCP1 have been reported, variations in CDCP1 post-translational modifications, such as phosphorylation and proteolytic cleavage, lead to functional changes that can influence cellular outcomes.
CDCP1 serves multiple cellular roles, primarily in signal transduction related to cell adhesion, migration, and survival:
Regulation of Cell Adhesion and Migration:
Survival Signaling:
Interactions with the Extracellular Matrix:
Role in Cancer Progression:
The clinical relevance of CDCP1 has been explored extensively in cancer biology, as its upregulation and activation correlate with aggressive tumor behavior. Specific clinical considerations include:
Prognostic Marker in Cancer:
Therapeutic Target:
Resistance to Anoikis:
Role in Other Diseases:
CDCP1, or CUB domain containing protein 1, is a transmembrane protein essential in cell signaling related to adhesion, migration, and survival. Its structure includes CUB domains in the extracellular region, a single-pass transmembrane domain, and intracellular tyrosine phosphorylation sites. These structural elements enable CDCP1 to modulate interactions with the ECM and activate signaling pathways critical for cell detachment, motility, and resistance to apoptosis.
Clinically, CDCP1 has emerged as an important molecule in cancer progression. Overexpressed and hyperphosphorylated in many tumors, CDCP1 contributes to invasion, metastasis, and survival of cancer cells, marking it as a prognostic indicator and potential therapeutic target. Therapeutic approaches targeting CDCP1 aim to reduce metastatic spread by inhibiting its adhesion-related and anti-apoptotic functions. CDCP1’s involvement in processes such as wound healing and tissue remodeling also suggests potential roles beyond oncology, although further research is necessary to understand these functions fully.
In conclusion, CDCP1’s structural characteristics and functional roles underscore its significance in both normal physiology and cancer pathology. Its influence on cell behavior positions it as a critical factor in metastatic disease, and ongoing research may reveal additional therapeutic and diagnostic opportunities related to this protein.
CUB domain containing protein 1 (CDCP1)
Membrane glycoprotein gp140,CD318,TRASK,SIMA135,Subtractive immunization M plus HEp3-associated 135 kDa protein
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, CLIA Kits, Primary Antibodies, ELISA Kits) relacionados con CDCP1 - CUB domain containing protein 1
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Esta página contiene 27 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | CDCP1 | abx190344 | Human CUB Domain Containing Protein 1 (CDCP1) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 27.4 pg/ml - 20000 pg/ml | < 10.7 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | CDCP1 | abx151010 | Human CUB Domain Containing Protein 1 (CDCP1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.13 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | CDCP1 | abx388941 | Mouse CUB Domain Containing Protein 1 (CDCP1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | Q5U462 | RUO |
FineTest | CDCP1 | EH7263 | Human CDCP1 (CUB domain-containing protein 1) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q9H5V8 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | CDCP1 | FNab01545 | anti- CDCP1 antibody | human | polyclonal | Rabbit | CUB domain containing protein 1 | IgG | Unconjugated | ELISA, WB | 100µg | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx140650 | CUB Domain-Containing Protein 1 (CDCP1) Antibody (FITC) | Human | Monoclonal | Mouse | CUB Domain-Containing Protein 1 (CDCP1) | FITC | FCM | 350 | 0.1 mg | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx320459 | CUB Domain Containing Protein 1 (CDCP1) Antibody | Human | Polyclonal | Rabbit | CUB Domain Containing Protein 1 (CDCP1) | Unconjugated | ELISA, IHC | 237.5 | 50 µl | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx140894 | CUB Domain-Containing Protein 1 (CDCP1) Antibody | Human | Monoclonal | Mouse | CUB Domain-Containing Protein 1 (CDCP1) | Unconjugated | FCM | 287.5 | 0.1 mg | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx224322 | CUB Domain-Containing Protein 1 (CDCP1) Antibody | Human | Monoclonal | Mouse | CUB Domain-Containing Protein 1 (CDCP1) | ELISA, WB, FCM | 362.5 | 100 µl | O95931 | RUO | ||
Abbexa | CDCP1 | abx028768 | CUB Domain Containing Protein 1 (CDCP1) Antibody | Human | Polyclonal | Rabbit | CUB Domain Containing Protein 1 (CDCP1) | Unconjugated | ELISA, WB | 250 | 80 µl | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx140642 | CUB Domain-Containing Protein 1 (CDCP1) Antibody (APC) | Human | Monoclonal | Mouse | CUB Domain-Containing Protein 1 (CDCP1) | APC | FCM | 400 | 100 tests | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx140651 | CUB Domain-Containing Protein 1 (CDCP1) Antibody (PE) | Human | Monoclonal | Mouse | CUB Domain-Containing Protein 1 (CDCP1) | PE | FCM | 400 | 0.1 mg | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx171963 | CUB Domain Containing Protein 1 (CDCP1) Antibody | Human | Monoclonal | Mouse | CUB Domain Containing Protein 1 (CDCP1) | Unconjugated | WB, IHC, IF/ICC | 750 | 1 ml | RUO | ||
Abbexa | CDCP1 | abx339984 | CUB Domain Containing Protein 1 (CDCP1) Antibody | Human | Polyclonal | Rabbit | CUB Domain Containing Protein 1 (CDCP1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx129082 | CUB Domain Containing Protein 1 (CDCP1) Antibody | Human | Polyclonal | Rabbit | CUB Domain Containing Protein 1 (CDCP1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx339925 | CUB Domain Containing Protein 1 (CDCP1) Antibody | Human | Polyclonal | Rabbit | CUB Domain Containing Protein 1 (CDCP1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx325689 | CUB Domain Containing Protein 1 (CDCP1) Antibody | Human | Polyclonal | Rabbit | CUB Domain Containing Protein 1 (CDCP1) | Unconjugated | ELISA, WB, IF/ICC | 187.5 | 50 µg | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx005767 | CUB Domain Containing Protein 1 (CDCP1) Antibody | Human | Polyclonal | Rabbit | CUB Domain Containing Protein 1 (CDCP1) | Unconjugated | WB | 175 | 20 µl | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx325373 | CUB Domain Containing Protein 1 Phospho-Tyr707 (CDCP1 pY707) Antibody | Human | Polyclonal | Rabbit | CUB Domain Containing Protein 1 Phospho-Tyr707 (CDCP1 pY707) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx325372 | CUB Domain Containing Protein 1 (CDCP1) Antibody | Human | Polyclonal | Rabbit | CUB Domain Containing Protein 1 (CDCP1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx402450 | CUB domain-containing protein 1 (CDCP1) Antibody | Human | Monoclonal | Human | CUB domain-containing protein 1 (CDCP1) | Unconjugated | ELISA | 287.5 | 50 µl | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx231545 | CUB Domain Containing Protein 1 (CDCP1) Antibody | Human | Polyclonal | Rabbit | CUB Domain Containing Protein 1 (CDCP1) | Unconjugated | ELISA, WB | 350 | 100 µg | Q9H5V8 | RUO | |
Abbexa | CDCP1 | abx327536 | CUB Domain Containing Protein 1 (CDCP1) Antibody | Human | Polyclonal | Rabbit | CUB Domain Containing Protein 1 (CDCP1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q9H5V8 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CDCP1 | abx691221 | Mouse CUB Domain Containing Protein 1 (CDCP1) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 962.5 | 100 µg | Q5U462 | RUO | |
Abbexa | CDCP1 | abx166064 | Human CUB Domain Containing Protein 1 (CDCP1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | CDCP1 | abx692432 | Mouse CUB Domain Containing Protein 1 (CDCP1) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 50 µg | Q5U462 | RUO | |
Abbexa | CDCP1 | abx680187 | Human CUB Domain Containing Protein 1 (CDCP1) Protein | Human | Recombinant | Insect | Unconjugated | SDS-PAGE | 300 | 1 µg | RUO |
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