Family main features
Bone morphogenetic protein receptor type 1A (BMPR1A) is a receptor for the bone morphogenetic proteins (BMPs), a subgroup of the transforming growth factor-beta (TGF-β) superfamily. BMPs are growth factors and cytokines that play critical roles in embryonic development, skeletal formation, organogenesis, and tissue homeostasis. BMPR1A, also known as ALK3 (Activin receptor-like kinase 3), specifically mediates BMP signaling by interacting with BMP ligands to activate intracellular pathways, influencing processes such as cell growth, differentiation, apoptosis, and repair. This receptor is essential for bone and cartilage development and has critical roles in several cell types across various tissues, with particularly strong influence in skeletal, cardiac, and gastrointestinal systems.
BMPR1A is a type I transmembrane serine/threonine kinase receptor that is structurally and functionally distinct in its ability to bind BMP ligands and initiate BMP-specific signaling cascades. Its protein structure can be divided into three main domains:
Extracellular Ligand-Binding Domain:
Transmembrane Domain:
Cytoplasmic Serine/Threonine Kinase Domain:
BMPR1A belongs to the type I TGF-β receptor family and is one of two main type I receptors for BMP signaling, the other being BMPR1B. Both BMPR1A and BMPR1B can bind BMP ligands, but they exhibit differences in ligand affinity, tissue distribution, and functional roles.
The type II BMP receptors (BMPR2, ActRIIA, and ActRIIB) are also involved in BMP signaling by partnering with BMPR1A to form heteromeric complexes with the ligand, facilitating full activation of the pathway.
BMPR1A’s primary function is to mediate BMP signaling, a pathway that plays a fundamental role in cellular growth and differentiation, especially during development. Key functional roles of BMPR1A include:
Bone and Cartilage Formation:
Developmental Processes:
Gastrointestinal Regulation:
Immunomodulatory Roles:
Given its fundamental roles in development and tissue homeostasis, BMPR1A mutations or dysregulation are associated with various clinical conditions:
Juvenile Polyposis Syndrome (JPS):
Hereditary Cancer Predisposition:
Bone and Skeletal Disorders:
Congenital Malformations:
BMPR1A, a type I BMP receptor, is essential in mediating bone morphogenetic protein signaling, influencing cell growth, differentiation, and development. The receptor has a highly specific structure with extracellular ligand-binding and intracellular kinase domains that allow it to interact with BMP ligands and activate SMAD-dependent signaling pathways. BMPR1A is particularly important in the development and maintenance of skeletal, gastrointestinal, and other organ systems, promoting balanced cell growth and differentiation.
Clinically, BMPR1A mutations are linked to juvenile polyposis syndrome and increased cancer susceptibility in the gastrointestinal tract, emphasizing its role in epithelial cell regulation. Additionally, alterations in BMPR1A signaling are implicated in various congenital malformations and bone disorders, highlighting its importance in developmental biology and disease prevention. Its role in maintaining tissue homeostasis and preventing overproliferation of stem cells in tissues like the intestine marks BMPR1A as a key regulator in both normal physiology and pathology.
bone morphogenetic protein receptor type 1A (BMPR1A)
Activin receptor-like kinase 3,ALK3,SKR5,ALK-3,CD292,ACVRLK3,BMPR-1A,Serine/threonine-protein kinase receptor R5
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, CLIA Kits, ELISA Kits, Primary Antibodies) relacionados con BMPR1A - bone morphogenetic protein receptor type 1A
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Esta página contiene 43 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | BMPR1A | abx490775 | Cow Bone Morphogenetic Protein Receptor 1A (BMPR1A) CLIA Kit | Cow | Tissue homogenates and other biological fluids. | Sandwich | 1.56 ng/ml - 100 ng/ml | < 0.53 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | BMPR1A | abx150080 | Cow Bone Morphogenetic Protein Receptor 1A (BMPR1A) ELISA Kit | Cow | Tissue homogenates,Other biological fluids | Sandwich | 1.56 ng/ml - 100 ng/ml | < 0.53 ng/ml | 712.5 | 96 tests | RUO | |
FineTest | BMPR1A | EH0703 | Human BMPR1A(Bone morphogenetic protein receptor type-1A) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.313-20ng/ml | 96T | P36894 | RUO | ||
Abbexa | BMPR1A | abx571972 | Human Bone Morphogenetic Protein Receptor 1A (BMPR1A) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 525 | 96 tests | P36894 | RUO |
Abbexa | BMPR1A | abx054562 | Human Bone Morphogenetic Protein Receptor 1A (BMPR1A) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 0.08 ng/ml - 5 ng/ml | 0.05 ng/ml | 587.5 | 96 tests | RUO | |
Abbexa | BMPR1A | abx490776 | Mouse Bone Morphogenetic Protein Receptor 1A (BMPR1A) CLIA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.057 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | BMPR1A | abx054563 | Mouse Bone Morphogenetic Protein Receptor 1A (BMPR1A) ELISA Kit | Mouse | Tissue homogenates,Other biological fluids | Sandwich | 33 pg/ml - 2000 pg/ml | 618.75 | 96 tests | RUO | ||
Abbexa | BMPR1A | abx153724 | Mouse Bone Morphogenetic Protein Receptor 1A (BMPR1A) ELISA Kit | Mouse | Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | BMPR1A | abx570043 | Mouse Bone Morphogenetic Protein Receptor 1A (BMPR1A) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 587.5 | 96 tests | P36895 | RUO |
FineTest | BMPR1A | ER0773 | Rat BMPR-1A(Bone Morphogenetic Protein Receptor 1A) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.781-50ng/ml | 96T | Q78EA7 | RUO | ||
Abbexa | BMPR1A | abx490777 | Rat Bone Morphogenetic Protein Receptor 1A (BMPR1A) CLIA Kit | Rat | Tissue homogenates and other biological fluids. | Sandwich | 0.781 ng/ml - 50 ng/ml | < 0.24 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | BMPR1A | abx196759 | Rat Bone Morphogenetic Protein Receptor 1A (BMPR1A) CLIA Kit | Rat | Serum, plasma and other biological fluids. | 0.156 ng/ml - 10 ng/ml | 0.1 ng/ml | 618.75 | 96 tests | RUO | ||
Abbexa | BMPR1A | abx054564 | Rat Bone Morphogenetic Protein Receptor 1A (BMPR1A) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | 0.47 ng/ml | 531.25 | 96 tests | Q78EA7 | RUO |
Abbexa | BMPR1A | abx155268 | Rat Bone Morphogenetic Protein Receptor 1A (BMPR1A) ELISA Kit | Rat | Tissue homogenates,Other biological fluids | Sandwich | 0.78 ng/ml - 50 ng/ml | < 0.24 ng/ml | 675 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | BMPR1A | FNab00922 | anti- BMPR1A antibody | human | polyclonal | Rabbit | bone morphogenetic protein receptor, type IA | IgG | Unconjugated | ELISA, WB, IF, IP | 100µg | P36894 | RUO | |
Abbexa | BMPR1A | abx036683 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | BMPR1A | abx301143 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | P36894 | RUO | |
Abbexa | BMPR1A | abx303213 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody (Biotin) | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Biotin | ELISA | 162.5 | 20 µg | P36894 | RUO | |
Abbexa | BMPR1A | abx031353 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | P36894 | RUO | |
Abbexa | BMPR1A | abx432420 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Human | Polyclonal | Goat | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | BMPR1A | abx031354 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | ELISA, WB, IF/ICC | 250 | 80 µl | P36894 | RUO | |
Abbexa | BMPR1A | abx323806 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | ELISA, WB | 187.5 | 50 µg | P36894 | RUO | |
Abbexa | BMPR1A | abx303212 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody (FITC) | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | FITC | 162.5 | 20 µg | P36894 | RUO | ||
Abbexa | BMPR1A | abx015777 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Human | Monoclonal | Mouse | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | ELISA, IHC, FCM | 362.5 | 100 µl | P36894 | RUO | |
Abbexa | BMPR1A | abx031355 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | ELISA, WB, IHC | 281.25 | 50 µl | P36894 | RUO | |
Abbexa | BMPR1A | abx031357 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | ELISA, WB, FCM | 281.25 | 80 µl | P36894 | RUO | |
Abbexa | BMPR1A | abx303211 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody (HRP) | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | HRP | ELISA | 162.5 | 20 µg | P36894 | RUO | |
Abbexa | BMPR1A | abx031356 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | ELISA, WB, FCM | 250 | 80 µl | P36894 | RUO | |
Abbexa | BMPR1A | abx015776 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Human | Monoclonal | Mouse | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | ELISA, WB, IHC, IF/ICC, FCM | 362.5 | 100 µl | RUO | ||
Abbexa | BMPR1A | abx001501 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | WB | 175 | 20 µl | P36894 | RUO | |
Abbexa | BMPR1A | abx111242 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | ELISA, WB | 612.5 | 100 µl | P36894 | RUO | |
Abbexa | BMPR1A | abx230922 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Human | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | ELISA, WB, IF/ICC, IP | 350 | 100 µg | P36894 | RUO | |
Abbexa | BMPR1A | abx130231 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Rat | Polyclonal | Rabbit | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q78EA7 | RUO | |
Abbexa | BMPR1A | abx171452 | Bone Morphogenetic Protein Receptor 1A (BMPR1A) Antibody | Rat | Monoclonal | Mouse | Bone Morphogenetic Protein Receptor 1A (BMPR1A) | Unconjugated | WB, IHC, IF/ICC | 775 | 1 ml | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | BMPR1A | abx262082 | BMPR1A Protein | Human | Recombinant | Unconjugated | SDS-PAGE | 225 | 2 µg | P36894 | RUO | |
Abbexa | BMPR1A | abx651050 | Human Bone Morphogenetic Protein Receptor 1A (BMPR1A) Peptide (OVA) | Human | Synthetic | OVA | WB, SDS-PAGE | 425 | 100 µg | RUO | ||
Abbexa | BMPR1A | abx691923 | Mouse Bone Morphogenetic Protein Receptor 1A (BMPR1A) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 962.5 | 200 µg | RUO | ||
Abbexa | BMPR1A | abx691374 | Mouse Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) Protein | Mouse | Recombinant | Human | SDS-PAGE | 162.5 | 10 µg | P36895 | RUO | |
Abbexa | BMPR1A | abx652695 | Mouse Bone Morphogenetic Protein Receptor 1A (BMPR1A) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 1800 | 1 mg | RUO | |
Abbexa | BMPR1A | abx652697 | Cow Bone Morphogenetic Protein Receptor 1A (BMPR1A) Protein | Cow | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 2112.5 | 1 mg | RUO | |
Abbexa | BMPR1A | abx166010 | Rat Bone Morphogenetic Protein Receptor 1A (BMPR1A) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q78EA7 | RUO |
FineTest | BMPR1A | P2854 | Recombinant Human BMPR1A | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | P36894 | RUO | ||
Abbexa | BMPR1A | abx652694 | Human Bone Morphogenetic Protein Receptor 1A (BMPR1A) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | RUO |
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