Family main features
CBFA2T, also known as CBFA2/RUNX1 Partner Transcriptional Co-Repressor, is a crucial protein involved in the regulation of gene expression. It was originally identified as a fusion partner in the t(8;21) chromosomal translocation commonly found in acute myeloid leukemia (AML). This translocation results in the creation of the RUNX1-ETO (also known as AML1-ETO) fusion protein, which disrupts normal hematopoiesis and contributes to leukemogenesis. CBFA2T is part of a larger family of proteins known as the ETO (Eight Twenty-One) family, which are characterized by their roles in transcriptional repression and chromatin remodeling.
CBFA2T proteins typically have several conserved domains that facilitate their function:
The modular structure of CBFA2T allows it to interact with various partners and integrate multiple signaling pathways to modulate gene expression.
The CBFA2T family includes several members, with CBFA2T1, CBFA2T2, and CBFA2T3 being the most studied. Each member has unique and overlapping functions in different tissues and developmental stages:
CBFA2T proteins are primarily involved in transcriptional repression. They function by recruiting histone deacetylases (HDACs) and other chromatin remodeling complexes to specific gene promoters, leading to a closed chromatin conformation and suppression of gene expression. This repression is crucial for regulating genes involved in cell differentiation, proliferation, and apoptosis.
CBFA2T proteins, including CBFA2T1, CBFA2T2, and CBFA2T3, are vital transcriptional co-repressors involved in regulating gene expression through chromatin remodeling. Their roles in normal hematopoiesis and neurogenesis underscore their importance in development and disease. The t(8;21) translocation and resulting RUNX1-ETO fusion protein are particularly significant in the context of AML, illustrating the critical impact of CBFA2T dysregulation in leukemogenesis. Understanding the detailed mechanisms of CBFA2T function and its interactions with other cellular pathways continues to be an important area of research, with implications for targeted therapies in cancer and other diseases.
CBFA2/RUNX1 partner transcriptional co-repressor 2 (CBFA2T2)
EHT,p85,MTGR1,ZMYND3,ETO homologous on chromosome 20,CBFA2/RUNX1 translocation partner 2,Myeloid translocation-related protein 1
CBFA2/RUNX1 partner transcriptional co-repressor 3 (CBFA2T3)
ETO2,MTG16,MTGR2,ZMYND4,RUNX1T3,Zinc finger MYND domain-containing protein 4,Myeloid translocation gene on chromosome 16 protein
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits) relacionados con CBFA2T - CBFA2/RUNX1 partner transcriptional co-repressor
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 20 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | CBFA2T2 | abx386306 | Human Protein CBFA2T2 (CBFA2T2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.19 ng/ml | 687.5 | 96 tests | O43439 | RUO |
Abbexa | CBFA2T3 | abx386307 | Human Protein CBFA2T3 (CBFA2T3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.313 ng/ml - 20 ng/ml | < 0.19 ng/ml | 687.5 | 96 tests | O75081 | RUO |
Abbexa | CBFA2T2 | abx533898 | Mouse Protein CBFA2T2 (CBFA2T2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O70374 | RUO | ||
Abbexa | CBFA2T3 | abx533893 | Mouse Protein CBFA2T3 (CBFA2T3) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O54972 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | CBFA2T2 | FNab01315 | anti- CBFA2T2 antibody | human | polyclonal | Rabbit | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | IgG | Unconjugated | ELISA, WB, IHC | 100µg | O43439 | RUO | |
FineTest | CBFA2T3 | FNab01316 | anti- CBFA2T3 antibody | human | polyclonal | Rabbit | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 | IgG | Unconjugated | ELISA, WB | 100µg | O75081 | RUO | |
Abbexa | CBFA2T2 | abx321846 | Protein CBFA2T2 (CBFA2T2) Antibody | Human | Polyclonal | Rabbit | Protein CBFA2T2 (CBFA2T2) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | O43439 | RUO | |
Abbexa | CBFA2T2 | abx340017 | Protein CBFA2T2 (CBFA2T2) Antibody | Human | Polyclonal | Rabbit | Protein CBFA2T2 (CBFA2T2) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | CBFA2T2 | abx028691 | Protein CBFA2T2 (CBFA2T2) Antibody | Human | Polyclonal | Rabbit | Protein CBFA2T2 (CBFA2T2) | Unconjugated | ELISA, WB, IF/ICC | 281.25 | 80 µl | O43439 | RUO | |
Abbexa | CBFA2T2 | abx321847 | Protein CBFA2T2 (CBFA2T2) Antibody | Human | Polyclonal | Rabbit | Protein CBFA2T2 (CBFA2T2) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | O43439 | RUO | |
Abbexa | CBFA2T2 | abx005323 | Protein CBFA2T2 (CBFA2T2) Antibody | Human | Polyclonal | Rabbit | Protein CBFA2T2 (CBFA2T2) | Unconjugated | WB, IF/ICC | 175 | 20 µl | O43439 | RUO | |
Abbexa | CBFA2T2 | abx231315 | Protein CBFA2T2 (CBFA2T2) Antibody | Human | Polyclonal | Rabbit | Protein CBFA2T2 (CBFA2T2) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | O43439 | RUO | |
Abbexa | CBFA2T2 | abx111800 | Protein CBFA2T2 (CBFA2T2) Antibody | Human | Polyclonal | Rabbit | Protein CBFA2T2 (CBFA2T2) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | O43439 | RUO | |
Abbexa | CBFA2T3 | abx341414 | Protein CBFA2T3 (CBFA2T3) Antibody | Human | Polyclonal | Rabbit | Protein CBFA2T3 (CBFA2T3) | Unconjugated | ELISA, WB, IHC | 162.5 | 20 µg | O75081 | RUO | |
Abbexa | CBFA2T3 | abx341416 | Protein CBFA2T3 (CBFA2T3) Antibody (FITC) | Human | Polyclonal | Rabbit | Protein CBFA2T3 (CBFA2T3) | FITC | 162.5 | 20 µg | O75081 | RUO | ||
Abbexa | CBFA2T3 | abx341415 | Protein CBFA2T3 (CBFA2T3) Antibody (HRP) | Human | Polyclonal | Rabbit | Protein CBFA2T3 (CBFA2T3) | HRP | ELISA | 162.5 | 20 µg | O75081 | RUO | |
Abbexa | CBFA2T3 | abx341417 | Protein CBFA2T3 (CBFA2T3) Antibody (Biotin) | Human | Polyclonal | Rabbit | Protein CBFA2T3 (CBFA2T3) | Biotin | ELISA | 162.5 | 20 µg | O75081 | RUO | |
Abbexa | CBFA2T3 | abx325197 | Protein CBFA2T3 (CBFA2T3) Antibody | Human | Polyclonal | Rabbit | Protein CBFA2T3 (CBFA2T3) | Unconjugated | ELISA, IHC | 187.5 | 50 µg | O75081 | RUO | |
Abbexa | CBFA2T3 | abx111801 | Protein CBFA2T3 (CBFA2T3) Antibody | Human | Polyclonal | Rabbit | Protein CBFA2T3 (CBFA2T3) | Unconjugated | ELISA, WB | 612.5 | 100 µl | O75081 | RUO | |
Abbexa | CBFA2T3 | abx231316 | Protein CBFA2T3 (CBFA2T3) Antibody | Human | Polyclonal | Rabbit | Protein CBFA2T3 (CBFA2T3) | Unconjugated | ELISA, WB | 350 | 100 µg | O75081 | RUO |
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