Human Protein CBFA2T3 (CBFA2T3) ELISA Kit
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Description
Human Protein CBFA2T3 (CBFA2T3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Core Binding Factor Alpha Subunit 2 Translocated To 3 (CBFa2T3) concentrations in tissue homogenates, cell lysates and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | Protein CBFA2T3 (CBFA2T3) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.19 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O75081 |
| Gene ID | 863 |
| OMIM | 603870 |
| Alias | ETO2,MTG16,MTGR2,ZMYND4,RUNX1T3,Zinc finger MYND domain-containing protein 4,Myeloid translocation gene on chromosome 16 protein |
| Background | Elisa kits for CBFA2T3 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
CBFA2/RUNX1 partner transcriptional co-repressor 3 (CBFA2T3) is another member of the CBFA2T family, acting as a co-repressor in the context of RUNX1-mediated transcription CBFA2T3 works similarly to CBFA2T2 by interacting with RUNX1 to repress gene expression, thereby playing a vital role in regulating hematopoietic development and function Like its counterpart, CBFA2T3 contributes to the maintenance of normal blood cell development by modulating gene expression that is essential for stem cell differentiation and lineage commitment It helps control processes like cell proliferation, differentiation, and apoptosis during hematopoiesis Mutations or alterations in CBFA2T3 expression can lead to hematologic disorders such as leukemia, where dysfunctional co-repression can disrupt the balance of cell growth and differentiation Understanding the role of CBFA2T3 in hematopoiesis could provide valuable insights into therapeutic strategies for blood cancers and other disorders related to abnormal gene regulation
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