Protein CBFA2T2 (CBFA2T2) Antibody
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935106861
info@markelab.com
Precio
195€ (20 µl)
Antibody anti-CBFA2T2
proveedor
Abbexareference
abx005323Tested Applications
ELISA, WB, IF/ICCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
CBFA2T2 Antibody is a Rabbit Polyclonal antibody against CBFA2T2. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Background
CBFA2/RUNX1 partner transcriptional co-repressor 2 (CBFA2T2) is a transcriptional co-repressor that interacts with the RUNX1 transcription factor, a key regulator of hematopoiesis and blood cell development CBFA2T2 plays an essential role in regulating gene expression during hematopoietic stem cell differentiation and maturation by modulating the activity of RUNX1 It acts by repressing transcription in cooperation with RUNX1, thus influencing the development of different blood cell lineages such as red blood cells, white blood cells, and platelets Dysregulation of CBFA2T2 has been linked to various hematological diseases, including leukemia, where aberrant interactions between CBFA2T2 and RUNX1 can lead to altered gene expression and uncontrolled cell proliferation CBFA2T2’s function as a co-repressor is also implicated in controlling cellular growth, differentiation, and apoptosis, and understanding its role may provide insights into both normal hematopoiesis and blood cancers
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Protein CBFA2T2 (CBFA2T2)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IF/ICC
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
20 µl
size 2
100 µl
size 3
2 × 100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
CBFA2T2
dry ice
No
availability
Shipped within 5-10 working days.
alias
EHT,p85,MTGR1,ZMYND3,ETO homologous on chromosome 20,CBFA2/RUNX1 translocation partner 2,Myeloid translocation-related protein 1
uniprot id
NCBI accession
NP_005084.1
note
Concentration: 0.58 mg/ml -
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