Protein CBFA2T2 (CBFA2T2) Antibody

Background

CBFA2/RUNX1 partner transcriptional co-repressor 2 (CBFA2T2) is a transcriptional co-repressor that interacts with the RUNX1 transcription factor, a key regulator of hematopoiesis and blood cell development CBFA2T2 plays an essential role in regulating gene expression during hematopoietic stem cell differentiation and maturation by modulating the activity of RUNX1 It acts by repressing transcription in cooperation with RUNX1, thus influencing the development of different blood cell lineages such as red blood cells, white blood cells, and platelets Dysregulation of CBFA2T2 has been linked to various hematological diseases, including leukemia, where aberrant interactions between CBFA2T2 and RUNX1 can lead to altered gene expression and uncontrolled cell proliferation CBFA2T2’s function as a co-repressor is also implicated in controlling cellular growth, differentiation, and apoptosis, and understanding its role may provide insights into both normal hematopoiesis and blood cancers