Protein CBFA2T2 (CBFA2T2) Antibody
637€ (100 µl)
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Name
Protein CBFA2T2 (CBFA2T2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx111800
Tested Applications
ELISA, WB, IHC
Description
Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To, 2 Antibody is a Rabbit Polyclonal antibody against Core-Binding Factor, Runt Domain, Alpha Subunit 2; Translocated To, 2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Protein CBFA2T2 (CBFA2T2) Immunogen: Human CBFA2T2. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43439 |
| Gene ID | 9139 |
| NCBI Accession | NP_001028171.1, NM_001032999.2, NP_001034798.1, NM_001039709.1, NP_005084.1, NM_005093.3 |
| OMIM | 603672 |
| Alias | EHT,p85,MTGR1,ZMYND3,ETO homologous on chromosome 20,CBFA2/RUNX1 translocation partner 2,Myeloid translocation-related protein 1 |
| Background | Antibody anti-CBFA2T2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CBFA2/RUNX1 partner transcriptional co-repressor 2 (CBFA2T2) is a transcriptional co-repressor that interacts with the RUNX1 transcription factor, a key regulator of hematopoiesis and blood cell development CBFA2T2 plays an essential role in regulating gene expression during hematopoietic stem cell differentiation and maturation by modulating the activity of RUNX1 It acts by repressing transcription in cooperation with RUNX1, thus influencing the development of different blood cell lineages such as red blood cells, white blood cells, and platelets Dysregulation of CBFA2T2 has been linked to various hematological diseases, including leukemia, where aberrant interactions between CBFA2T2 and RUNX1 can lead to altered gene expression and uncontrolled cell proliferation CBFA2T2’s function as a co-repressor is also implicated in controlling cellular growth, differentiation, and apoptosis, and understanding its role may provide insights into both normal hematopoiesis and blood cancers
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