CBFA2T3 antibody
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Description
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes(PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner(PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway(PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A(PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes(By similarity). Plays a role in granulocyte differentiation(PubMed:15231665). Isoform 2 functions as an A-kinase-anchoring protein(PubMed:11823486).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (CBFA2T3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 62-65kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O75081 |
| Gene ID | 863 |
| Alias | ETO2,MTG16,MTGR2,ZMYND4,RUNX1T3,Zinc finger MYND domain-containing protein 4,Myeloid translocation gene on chromosome 16 protein |
| Background | Antibody anti-CBFA2T3 |
| Status | RUO |
| Note | Mol. Weight 62-65 kDa |
Descripción
CBFA2/RUNX1 partner transcriptional co-repressor 3 (CBFA2T3) is another member of the CBFA2T family, acting as a co-repressor in the context of RUNX1-mediated transcription CBFA2T3 works similarly to CBFA2T2 by interacting with RUNX1 to repress gene expression, thereby playing a vital role in regulating hematopoietic development and function Like its counterpart, CBFA2T3 contributes to the maintenance of normal blood cell development by modulating gene expression that is essential for stem cell differentiation and lineage commitment It helps control processes like cell proliferation, differentiation, and apoptosis during hematopoiesis Mutations or alterations in CBFA2T3 expression can lead to hematologic disorders such as leukemia, where dysfunctional co-repression can disrupt the balance of cell growth and differentiation Understanding the role of CBFA2T3 in hematopoiesis could provide valuable insights into therapeutic strategies for blood cancers and other disorders related to abnormal gene regulation
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